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Development of a colorectal cancer diagnostic model and dietary risk assessment through gut microbiome analysis
- Title
- Development of a colorectal cancer diagnostic model and dietary risk assessment through gut microbiome analysis
- Authors
- Yang, Jinho; McDowell, Andrea; Kim, Eun Kyoung; Seo, Hochan; Lee, Won Hee; Moon, Chang-Mo; Kym, Sung-Min; Lee, Dong Ho; Park, Young Soo; Jee, Young-Koo; Kim, Yoon-Keun
- Ewha Authors
- 문창모
- SCOPUS Author ID
- 문창모
- Issue Date
- 2019
- Journal Title
- EXPERIMENTAL AND MOLECULAR MEDICINE
- ISSN
- 1226-3613
2092-6413
- Citation
- EXPERIMENTAL AND MOLECULAR MEDICINE vol. 51
- Publisher
- NATURE PUBLISHING GROUP
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Colorectal cancer (CRC) is the third most common form of cancer and poses a critical public health threat due to the global spread of westernized diets high in meat, cholesterol, and fat. Although the link between diet and colorectal cancer has been well established, the mediating role of the gut microbiota remains elusive. In this study, we sought to elucidate the connection between the gut microbiota, diet, and CRC through metagenomic analysis of bacteria isolated from the stool of CRC (n = 89) and healthy (n = 161) subjects. This analysis yielded a dozen genera that were significantly altered in CRC patients, including increased Bacteroides, Fusobacterium, Dorea, and Porphyromonas prevalence and diminished Pseudomonas, Prevotella, Acinetobacter, and Catenibacterium carriage. Based on these altered genera, we developed two novel CRC diagnostic models through stepwise selection and a simplified model using two increased and two decreased genera. As both models yielded strong AUC values above 0.8, the simplified model was applied to assess diet-based CRC risk in mice. Mice fed a westernized high-fat diet (HFD) showed greater CRC risk than mice fed a regular chow diet. Furthermore, we found that nonglutinous rice, glutinous rice, and sorghum consumption reduced CRC risk in HFD-fed mice. Collectively, these findings support the critical mediating role of the gut microbiota in diet-induced CRC risk as well as the potential of dietary grain intake to reduce microbiota-associated CRC risk. Further study is required to validate the diagnostic prediction models developed in this study as well as the preventive potential of grain consumption to reduce CRC risk.
- DOI
- 10.1038/s12276-019-0313-4
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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