Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이지희 | * |
dc.contributor.author | 최윤희 | * |
dc.contributor.author | 김민석 | * |
dc.date.accessioned | 2019-10-29T16:30:32Z | - |
dc.date.available | 2019-10-29T16:30:32Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 2218-273X | * |
dc.identifier.other | OAK-25525 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/251668 | - |
dc.description.abstract | Previously, we demonstrated that growth arrest-specific protein 6 (Gas6)/Axl or Mer signaling inhibited the transforming growth factor (TGF)-beta 1-induced epithelial-mesenchymal transition (EMT) in lung epithelial cells. Hepatocyte growth factor (HGF) has also been shown to inhibit TGF-beta 1-induced changes in EMT markers. Here, we examined whether Gas6 signaling can induce the production of HGF and c-Met in lung alveolar epithelial cells to mediate the inhibition of EMT and to inhibit the migration and invasion of epithelial cells. The inhibition of the RhoA/Rho kinase pathway, using either a RhoA-targeted small interfering RNA (siRNA) or the Rho kinase pharmacologic inhibitor Y27362, prevented the inhibition of TGF-beta 1-induced EMT in LA-4 cells and primary alveolar type II (AT II) epithelial cells. The c-Met antagonist PHA-665752 also blocked the anti-EMT effects associated with Gas6. Moreover, treatment with Y27362 or PHA-665752 prevented the Gas6-mediated inhibition of TGF-beta 1-induced migration and invasion. Our data provided evidence that the RhoA-dependent production of HGF and c-Met mediated the Gas6-induced inhibition of EMT, migration and invasion in lung alveolar epithelial cells. Thus, Gas6/Axl and Mer/RhoA signaling may be necessary for the maintenance of homeostasis in the alveolar epithelium, via HGF and c-Met. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | growth arrest-specific protein 6 | * |
dc.subject | hepatocyte growth factor | * |
dc.subject | c-Met | * |
dc.subject | epithelial-mesenchymal transition | * |
dc.subject | lung epithelial cells | * |
dc.title | RhoA-Dependent HGF and c-Met Mediate Gas6-Induced Inhibition of Epithelial-Mesenchymal Transition, Migration, and Invasion of Lung Alveolar Epithelial Cells | * |
dc.type | Article | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | BIOMOLECULES | * |
dc.identifier.doi | 10.3390/biom9100565 | * |
dc.identifier.wosid | WOS:000497726800057 | * |
dc.identifier.scopusid | 2-s2.0-85072969273 | * |
dc.author.google | Jung, Jihye | * |
dc.author.google | Yang, Kyungwon | * |
dc.author.google | Kim, Hee-Ja | * |
dc.author.google | Lee, Ye-Ji | * |
dc.author.google | Kim, Minsuk | * |
dc.author.google | Choi, Youn-Hee | * |
dc.author.google | Kang, And Jihee Lee | * |
dc.contributor.scopusid | 이지희(7404517577) | * |
dc.contributor.scopusid | 최윤희(7404776849) | * |
dc.contributor.scopusid | 김민석(55686393700) | * |
dc.date.modifydate | 20240222124201 | * |