Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최규룡 | * |
dc.contributor.author | 박미혜 | * |
dc.contributor.author | 전루민 | * |
dc.contributor.author | 공경혜 | * |
dc.contributor.author | 한경은 | * |
dc.contributor.author | 최은오 | * |
dc.date.accessioned | 2019-10-29T16:30:32Z | - |
dc.date.available | 2019-10-29T16:30:32Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1556-9527 | * |
dc.identifier.issn | 1556-9535 | * |
dc.identifier.other | OAK-25529 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/251664 | - |
dc.description.abstract | Purpose: To compare the therapeutic effects of human derivatives in a mouse alkali burn model. Methods: The right eyes of mice were injured using NaOH. After alkali injury, one of the following agents was topically administered for 7 d: human amniotic membrane (hAM) suspension, human umbilical cord serum (hUCS), and human peripheral blood serum (hPBS), or saline. The epithelial defect areas on days 1, 2, and 3 degrees of opacity on days 2, 3, and 7, and corneal neovascularization (NV) areas on day 7 were evaluated. Histologic examination and mRNA expression levels of tumour necrosis factor (TNF)-alpha, interleukin (IL)-6, vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-2, MMP-8, and MMP-9 were also evaluated on day 7. Results: The epithelial defect areas in the hUCS group were smaller than those in the control and hPBS groups on day 3 (p < .05, respectively). The epithelial defect areas in the hAM suspension group showed smaller than those in the control and hPBS groups on days 1 and 2 (p < .05, respectively). The degrees of opacity were lower in all treatment groups than that of the saline control group on day 7 (p < .05, respectively). Corneal NV areas were not different among groups on day 7 (p = 0.20). The expression levels of TNF-alpha, IL-6, MMP-8, and MMP-9 mRNA and the infiltration of the inflammatory cells in all treatment groups were lesser than those in the control group on day 7 (p< .05, respectively). Conclusions: All treatments reduced inflammatory reactions and corneal opacity development. Corneal reepithelialization was faster in the hUCS group. | * |
dc.language | English | * |
dc.publisher | TAYLOR & | * |
dc.publisher | FRANCIS LTD | * |
dc.subject | Alkali injury | * |
dc.subject | peripheral blood serum | * |
dc.subject | umbilical cord serum | * |
dc.subject | amniotic membrane suspension | * |
dc.title | Therapeutic effects of three human-derived materials in a mouse corneal alkali burn model* | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 38 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 315 | * |
dc.relation.lastpage | 321 | * |
dc.relation.journaltitle | CUTANEOUS AND OCULAR TOXICOLOGY | * |
dc.identifier.doi | 10.1080/15569527.2019.1573244 | * |
dc.identifier.wosid | WOS:000477307800001 | * |
dc.identifier.scopusid | 2-s2.0-85073089444 | * |
dc.author.google | Han, Kyung Eun | * |
dc.author.google | Park, Mi Hye | * |
dc.author.google | Kong, Kyoung Hye | * |
dc.author.google | Choi, Euno | * |
dc.author.google | Choi, Kyu-Ryong | * |
dc.author.google | Jun, Roo Min | * |
dc.contributor.scopusid | 최규룡(7403949263) | * |
dc.contributor.scopusid | 박미혜(57218662303;58492640400) | * |
dc.contributor.scopusid | 전루민(6602278519) | * |
dc.contributor.scopusid | 공경혜(57204252400) | * |
dc.contributor.scopusid | 한경은(37031161100) | * |
dc.contributor.scopusid | 최은오(57211235738) | * |
dc.date.modifydate | 20240415131738 | * |