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A chromenone analog as an ATP-competitive, DNA non-intercalative topoisomerase II catalytic inhibitor with preferences toward the alpha isoform

Title
A chromenone analog as an ATP-competitive, DNA non-intercalative topoisomerase II catalytic inhibitor with preferences toward the alpha isoform
Authors
Park, SeojeongHwang, Soo-YeonShin, JaehoJo, HyunjiNa, YounghwaKwon, Youngjoo
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2019
Journal Title
CHEMICAL COMMUNICATIONS
ISSN
1359-7345JCR Link

1364-548XJCR Link
Citation
CHEMICAL COMMUNICATIONS vol. 55, no. 85, pp. 12857 - 12860
Publisher
ROYAL SOC CHEMISTRY
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
5-Hydroxy-2-phenyl-7-(thiiran-2-ylmethoxy)-4H-chromen-4-one (compound 52) was found as a DNA non-intercalative topo II specific catalytic inhibitor by targeting its ATP-binding domain. Showing changes in interaction with Mg2+, it exhibited highly selective properties against the alpha -isoform with less toxicity, unlike other topo II poisons, such as etoposide.
DOI
10.1039/c9cc05524j
Appears in Collections:
약학대학 > 약학과 > Journal papers
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