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The prognostic significance of preoperative tumor marker (CEA, CA15-3) elevation in breast cancer patients: data from the Korean Breast Cancer Society Registry
- Title
- The prognostic significance of preoperative tumor marker (CEA, CA15-3) elevation in breast cancer patients: data from the Korean Breast Cancer Society Registry
- Authors
- Nam, Sang Eun; Lim, Woosung; Jeong, Joon; Lee, Seeyoun; Choi, Jungeun; Park, HeungKyu; Jung, Yong Sik; Jung, Seung Pil; Bae, Soo Youn
- Ewha Authors
- 임우성
- SCOPUS Author ID
- 임우성
- Issue Date
- 2019
- Journal Title
- BREAST CANCER RESEARCH AND TREATMENT
- ISSN
- 0167-6806
1573-7217
- Citation
- BREAST CANCER RESEARCH AND TREATMENT vol. 177, no. 3, pp. 669 - 678
- Keywords
- Breast cancer; Tumor marker; CA15-3; CEA; Prognosis; Subtypes; Overall survival
- Publisher
- SPRINGER
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Purpose Tumor markers such as carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA15-3) are widely used for monitoring breast cancer. However, the prognostic efficacy of preoperative elevations of CEA and CA15-3 levels in breast cancer patients remains controversial. Methods We retrospectively analyzed the clinicopathological parameters of 149,238 patients in the Korean Breast Cancer Society Registry Database who underwent surgery between January 2000 and December 2015. Results The patients with elevated CA15-3/CEA levels had worse overall survival (OS) than the patients with normal CA15-3/CEA levels. For the luminal A subtype, the CA15-3- and CEA-elevated group had a hazard ratio (HR) of 2.14 (95% CI 1.01-4.55). The CA15-3-elevated group had an HR of 2.38 (95% CI 1.58-3.58) and the CEA-elevated group had an HR of 1.79 (95% CI 1.20-2.68) compared to the normal group. For the luminal B subtype, the CA15-3- and CEA-elevated group had an HR of 3.99 (95% CI 2.23-7.16), whereas the CA15-3-elevated group had an HR of 2.38 (95% CI 1.58-3.58) and the CEA-elevated group had an HR of 1.79 (95% CI 1.20-2.68). For the HER2 subtype, elevated CEA level was the only independent prognostic factor. However, for the triple-negative breast cancer (TNBC) subtype, elevated preoperative CEA and CA15-3 levels were not significant prognostic factors for OS. Conclusion Preoperative CEA and CA15-3 levels showed varying prognostic ability according to breast cancer subtype. Preoperative CA15-3 and CEA elevation are significant prognostic factors for luminal breast cancer, but they were not significant factors for TNBC.
- DOI
- 10.1007/s10549-019-05357-y
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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