Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상혁 | * |
dc.date.accessioned | 2019-10-02T02:00:08Z | - |
dc.date.available | 2019-10-02T02:00:08Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 0027-8424 | * |
dc.identifier.other | OAK-25403 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/251537 | - |
dc.description.abstract | RNA represents a pivotal component of host-pathogen interactions. Human cytomegalovirus (HCMV) infection causes extensive alteration in host RNA metabolism, but the functional relationship between the virus and cellular RNA processing remains largely unknown. Through loss-of-function screening, we show that HCMV requires multiple RNA-processing machineries for efficient viral lytic production. In particular, the cellular RNA-binding protein Roquin, whose expression is actively stimulated by HCMV, plays an essential role in inhibiting the innate immune response. Transcriptome profiling revealed Roquin-dependent global down-regulation of proinflammatory cytokines and antiviral genes in HCMV-infected cells. Furthermore, using cross-linking immunoprecipitation (CLIP)-sequencing (seq), we identified IFN regulatory factor 1 (IRF1), a master transcriptional activator of immune responses, as a Roquin target gene. Roquin reduces IRF1 expression by directly binding to its mRNA, thereby enabling suppression of a variety of antiviral genes. This study demonstrates how HCMV exploits host RNA-binding protein to prevent a cellular antiviral response and offers mechanistic insight into the potential development of CMV therapeutics. | * |
dc.language | English | * |
dc.publisher | NATL ACAD SCIENCES | * |
dc.subject | human cytomegalovirus | * |
dc.subject | RNA-binding protein | * |
dc.subject | immune evasion | * |
dc.subject | proinflammatory cytokine | * |
dc.title | Human cytomegalovirus induces and exploits Roquin to counteract the IRF1-mediated antiviral state | * |
dc.type | Article | * |
dc.relation.issue | 37 | * |
dc.relation.volume | 116 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 18619 | * |
dc.relation.lastpage | 18628 | * |
dc.relation.journaltitle | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | * |
dc.identifier.doi | 10.1073/pnas.1909314116 | * |
dc.identifier.wosid | WOS:000485145400070 | * |
dc.identifier.scopusid | 2-s2.0-85072051592 | * |
dc.author.google | Song, Jaewon | * |
dc.author.google | Lee, Sanghyun | * |
dc.author.google | Cho, Dong-Yeon | * |
dc.author.google | Lee, Sungwon | * |
dc.author.google | Kim, Hyewon | * |
dc.author.google | Yu, Namhee | * |
dc.author.google | Lee, Sanghyuk | * |
dc.author.google | Ahn, Kwangseog | * |
dc.contributor.scopusid | 이상혁(57212112170) | * |
dc.date.modifydate | 20240415122632 | * |