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Correlations between invasively measured aortic pressures and left ventricular end-diastolic pressure in patients undergoing coronary angiography
- Correlations between invasively measured aortic pressures and left ventricular end-diastolic pressure in patients undergoing coronary angiography
- Kim K.-J.; Kim H.-L.; Kang D.-Y.; Park S.-H.; Lim W.-H.; Seo J.-B.; Kim S.-H.; Zo J.-H.; Kim M.-A.
- Ewha Authors
- Issue Date
- Journal Title
- Blood pressure monitoring
- Blood pressure monitoring vol. 24, no. 5, pp. 241 - 247
- NLM (Medline)
- SCIE; SCOPUS
- Document Type
- OBJECTIVE: Data on ventricular-arterial coupling using invasive hemodynamic studies are limited. This study was performed to clarify the interaction between aortic pressures and left ventricular end-diastolic pressure (LVEDP) using invasive catheterization. PATIENTS AND METHODS: A total of 104 consecutive stable patients (mean age, 65.8 ± 10.0 years; 56% men) undergoing invasive coronary angiography (ICA) were prospectively evaluated. LVEDP and central aortic pressures [systolic blood pressure (aSBP) and diastolic blood pressure (aDBP)] were sequentially measured using a pigtail catheter before ICA. Aortic pulse pressure (aPP) was defined by the difference between aSBP and aDBP. RESULTS: A total of 82 patients (79%) had obstructive coronary artery disease (≥50% stenosis). The mean LVEDP value was 18.7 ± 6.4 mmHg. Univariable analyses showed that aSBP (r = 0.309, P = 0.001) and aPP (r = 0.286, P = 0.003) significantly correlated with LVEDP, whereas aDBP was not correlated with LVEDP (P > 0.05). Multivariable analysis revealed that aSBP (β = 0.345, P = 0.001) and aPP (β = 0.276, P = 0.018) remained independent predictors of LVEDP even after controlling for potential confounders. CONCLUSION: Invasively measured aSBP and aPP were independently associated with invasively measured LVEDP in patients undergoing ICA. This result provides additional evidence of a close interaction between central aortic pressure and LV diastolic function in this population.
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