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Tonsil-derived stem cells as a new source of adult stem cells
- Title
- Tonsil-derived stem cells as a new source of adult stem cells
- Authors
- Cho, Kyung-Ah; Lee, Hyun Jung; Jeong, Hansaem; Kim, Miri; Jung, Soo Yeon; Park, Hae Sang; Ryu, Kyung-Ha; Lee, Seung Jin; Jeong, Byeongmoon; Lee, Hyukjin; Kim, Han Su
- Ewha Authors
- 이승진; 유경하; 정병문; 김한수; 이혁진; 조경아; 정수연
- SCOPUS Author ID
- 이승진; 유경하; 정병문; 김한수; 이혁진; 조경아; 정수연
- Issue Date
- 2019
- Journal Title
- WORLD JOURNAL OF STEM CELLS
- ISSN
- 1948-0210
- Citation
- WORLD JOURNAL OF STEM CELLS vol. 11, no. 8, pp. 506 - 518
- Keywords
- Stem cell; Tonsil-derived stem cell; Differentiation; Endoderm; Mesoderm; Ectoderm; Cell therapy
- Publisher
- BAISHIDENG PUBLISHING GROUP INC
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Located near the oropharynx, the tonsils are the primary mucosal immune organ. Tonsil tissue is a promising alternative source for the high-yield isolation of adult stem cells, and recent studies have reported the identification and isolation of tonsil-derived stem cells (T-SCs) from waste surgical tissue following tonsillectomies in relatively young donors (i.e., under 10 years old). As such, T-SCs offer several advantages, including superior proliferation and a shorter doubling time compared to bone marrow-derived mesenchymal stem cells (MSCs). T-SCs also exhibit multi-lineage differentiation, including mesodermal, endodermal (e.g., hepatocytes and parathyroid-like cells), and even ectodermal cells (e.g., Schwann cells). To this end, numbers of researchers have evaluated the practical use of T-SCs as an alternative source of autologous or allogenic MSCs. In this review, we summarize the details of T-SC isolation and identification and provide an overview of their application in cell therapy and regenerative medicine.
- DOI
- 10.4252/wjsc.v11.i8.506
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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Tonsil-derived stem cells.pdf(2.22 MB)
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