Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 장중현 | * |
dc.date.accessioned | 2019-10-02T02:00:03Z | - |
dc.date.available | 2019-10-02T02:00:03Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1471-2334 | * |
dc.identifier.other | OAK-25368 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/251502 | - |
dc.description.abstract | BackgroundAlthough the incidence of tuberculosis (TB) has decreased in South Korea, the mortality rate remains high. TB mortality is a key indicator for TB control interventions. The purpose of this study was to assess early and TB-related mortality during anti-TB treatment and describe the associated clinical characteristics.MethodsA multicenter cross-sectional study was performed across South Korea. Patients with pulmonary TB who died during anti-TB treatment and whose records were submitted to the national TB surveillance system between 2015 and 2017 were enrolled. All TB deaths were categorized based on cause (TB-related or non-TB-related) and timing (early or late). We identified statistical associations using the frequency table, chi-square test, and binary logistic regression.ResultsOf 5595 notifiable mortality cases, 3735 patients with pulmonary TB were included in the analysis. There were 2541 (68.0%) male patients, and 2935 (78.6%) mortality cases were observed in patients older than 65years. There were 944 (25.3%) cases of TB-related death and 2545 (68.1%) cases of early death. Of all cases, 187 (5.0%) patients were diagnosed post-mortem and 38 (1.0%) patients died on the first day of treatment. Low body mass index (adjusted odds ratio (aOR)=1.26; 95% confidence interval (CI)=1.08-1.48), no reported illness (aOR=1.36; 95% CI=1.10-1.68), bilateral disease on chest X-ray (aOR=1.30; 95% CI=1.11-1.52), and positive acid-fast bacilli smear result (aOR=1.30; 95% CI=1.11-1.52) were significantly associated with early death, as well as TB-related death. Acute respiratory failure was the most common mode of non-TB-related death. Malignancy was associated with both late (aOR=0.71; 95% CI=0.59-0.89) and non-TB-related (aOR=0.35; 95% CI=0.26-0.46) death.ConclusionsA high proportion of TB death was observed in elderly patients and attributed to non-TB-related causes. Many TB-related deaths occurred during the intensive phase, particularly within the first month. Further studies identifying risk factors for different causes of TB death at different phases of anti-TB treatment are warranted for early targeted intervention in order to reduce TB mortality. | * |
dc.language | English | * |
dc.publisher | BMC | * |
dc.subject | Private-public mix | * |
dc.subject | PPM | * |
dc.subject | Death | * |
dc.subject | Elderly | * |
dc.subject | Korea | * |
dc.title | Clinical profiles of early and tuberculosis-related mortality in South Korea between 2015 and 2017: a cross-sectional study | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 19 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | BMC INFECTIOUS DISEASES | * |
dc.identifier.doi | 10.1186/s12879-019-4365-9 | * |
dc.identifier.wosid | WOS:000483312400001 | * |
dc.identifier.scopusid | 2-s2.0-85071233741 | * |
dc.author.google | Min, Jinsoo | * |
dc.author.google | Kim, Ju Sang | * |
dc.author.google | Kim, Hyung Woo | * |
dc.author.google | Shin, Ah Young | * |
dc.author.google | Koo, Hyeon-Kyoung | * |
dc.author.google | Lee, Sung-Soon | * |
dc.author.google | Kim, Yang-Ki | * |
dc.author.google | Shin, Kyeong-Cheol | * |
dc.author.google | Chang, Jung Hyun | * |
dc.author.google | Chun, Gayoung | * |
dc.author.google | Lee, Joosun | * |
dc.author.google | Park, Mi Sun | * |
dc.author.google | Park, Jae Seuk | * |
dc.contributor.scopusid | 장중현(57193227620) | * |
dc.date.modifydate | 20240415132519 | * |