Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권기환 | * |
dc.contributor.author | 정지화 | * |
dc.contributor.author | 권경애 | * |
dc.date.accessioned | 2019-10-02T02:00:02Z | - |
dc.date.available | 2019-10-02T02:00:02Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 2045-2322 | * |
dc.identifier.other | OAK-25364 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/251498 | - |
dc.description.abstract | Doxorubicin (DOX) is a widely used anti-cancer drug; however, it has limited application due to cardiotoxicity. Extracorporeal shock waves (ESW) have been suggested to treat inflammatory and ischemic diseases, but the concrete effect of ESW in DOX-induced cardiomyopathy remain obscure. After H9c2 cells were subjected to ESW (0.04 mJ/cm2), they were treated with 1 μM DOX. As a result, ESW protected cardiomyocytes from DOX-induced cell death. H9c2 cells treated with DOX downregulated p-Akt and survivin expression, whereas the ESW treatment recovered both, suggesting its anti-apoptotic effect. ESW activated integrin αvβ3 and αvβ5, cardiomyocyte mechanosensors, followed by upregulation of ILK, p-Akt and survivin levels. Further, Sp1 and p53 were determined as key transcriptional factors mediating survivin expression via Akt phosphorylation by ESW. In in vivo acute DOX-induced cardiomyopathy model, the echocardiographic results showed that group subjected to ESW recovered from acute DOX-induced cardiomyopathy; left ventricular function was improved. The immunohistochemical staining results showed increased survivin and Bcl2 expression in ESW + DOX group compared to those in the DOX-injected group. In conclusion, non-invasive shockwaves protect cardiomyocytes from DOX-induced cardiomyopathy by upregulating survivin via integrin-ILK-Akt-Sp1/p53 pathway. In vivo study proposed ESW as a new kind of specific and safe therapy against acute DOX-induced cardiomyopathy. © 2019, The Author(s). | * |
dc.language | English | * |
dc.publisher | Nature Publishing Group | * |
dc.title | Extracorporeal shock waves protect cardiomyocytes from doxorubicin-induced cardiomyopathy by upregulating survivin via the integrin-ILK-Akt-Sp1/p53 axis | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Scientific Reports | * |
dc.identifier.doi | 10.1038/s41598-019-48470-0 | * |
dc.identifier.wosid | WOS:000481999500003 | * |
dc.identifier.scopusid | 2-s2.0-85071004230 | * |
dc.author.google | Yoon Lee J. | * |
dc.author.google | Chung J. | * |
dc.author.google | Hwa Kim K. | * |
dc.author.google | Hyun An S. | * |
dc.author.google | Yi J.-E. | * |
dc.author.google | Ae Kwon K. | * |
dc.author.google | Kwon K. | * |
dc.contributor.scopusid | 권기환(57203037966) | * |
dc.contributor.scopusid | 정지화(55774529800) | * |
dc.contributor.scopusid | 권경애(57210584253) | * |
dc.date.modifydate | 20240118164632 | * |