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Cough-related laryngeal sensations and triggers in adults with chronic cough: Symptom profile and impact
- Title
- Cough-related laryngeal sensations and triggers in adults with chronic cough: Symptom profile and impact
- Authors
- Won H.-K.; Kang S.-Y.; Kang Y.; An J.; Lee J.-H.; Lee S.M.; Kwon J.-W.; Kim M.-H.; Jo E.-J.; Lee S.-E.; Kim S.-H.; Chang Y.-S.; Lee B.-J.; Cho S.-H.; Birring S.S.; Song W.-J.
- Ewha Authors
- 김민혜
- SCOPUS Author ID
- 김민혜
- Issue Date
- 2019
- Journal Title
- Allergy, Asthma and Immunology Research
- ISSN
- 2092-7355
- Citation
- Allergy, Asthma and Immunology Research vol. 11, no. 5, pp. 622 - 631
- Keywords
- Cough; Hypersensitivity; Symptom assessment
- Publisher
- Korean Academy of Asthma, Allergy and Clinical Immunology
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Purpose: Recent evidence suggests that cough hypersensitivity may be a common feature of chronic cough in adults. However, the clinical relevance remains unclear. This study evaluated the cough-related symptom profile and the clinical relevance and impact of cough hypersensitivity in adults with chronic cough. Methods: This cross-sectional multi-center study compared cough-related laryngeal sensations and cough triggers in patients with unexplained chronic cough following investigations and in unselected patients newly referred for chronic cough. A structured questionnaire was used to assess abnormal laryngeal sensations and cough triggers. Patients with unexplained cough were also evaluated using the Leicester Cough Questionnaire (LCQ) and a cough visual analogue scale (VAS), and these scores were assessed for correlations with the number of triggers and laryngeal sensations. Results: This study recruited 478 patients, including 62 with unexplained chronic cough and 416 with chronic cough. Most participants reported abnormal laryngeal sensations and cough triggers. Laryngeal sensations (4.4 ± 1.5 vs. 3.9 ± 1.9; P = 0.049) and cough triggers (6.9 ± 2.6 vs. 5.0 ± 2.8; P < 0.001) were more frequent in patients with unexplained chronic cough than in those with chronic cough. The number of triggers and laryngeal sensations score significantly correlated with LCQ (r = -0.51, P < 0.001) and cough VAS score (r = 0.53, P < 0.001) in patients with unexplained chronic cough. Conclusions: Cough hypersensitivity may be a common feature in adult patients with chronic cough, especially those with unexplained chronic cough. Cough-related health status and cough severity were inversely associated with the number of triggers and laryngeal sensations, suggesting potential relevance of assessing cough hypersensitivity in chronic cough patients. © 2019 The Korean Academy of Asthma.
- DOI
- 10.4168/aair.2019.11.5.622
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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