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Meroindenon and Merochlorins e and F, Antibacterial Meroterpenoids from a Marine-Derived Sediment Bacterium of the Genus Streptomyces

Title
Meroindenon and Merochlorins e and F, Antibacterial Meroterpenoids from a Marine-Derived Sediment Bacterium of the Genus Streptomyces
Authors
Ryu M.-J.Hwang S.Kim S.Yang I.Oh D.-C.Nam S.-J.Fenical W.
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2019
Journal Title
Organic Letters
ISSN
1523-7060JCR Link
Citation
Organic Letters vol. 21, no. 15, pp. 5779 - 5783
Publisher
American Chemical Society
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Meroterpenoids, meroindenon (1) and merochlorins E (2) and F (3), were isolated from a marine-derived bacterium belonging to the genus Streptomyces. Their chemical structures were established using extensive analysis of MS, UV, ECD, and NMR spectroscopic data. Compounds 1-3 possess a tetrahydroxynaphthalene core and a C15-isoprene unit. Compounds 2 and 3 exhibited strong antibacterial activities against B. subtilis, K. rhizophila, and S. aureus, with a range of MIC values from 1 to 2 μg/mL. Copyright © 2019 American Chemical Society.
DOI
10.1021/acs.orglett.9b01440
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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