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The Association Between Mercury Exposure and Atopic Dermatitis in Early Childhood A Mothers and Children's Environmental Health Study

Title
The Association Between Mercury Exposure and Atopic Dermatitis in Early Childhood A Mothers and Children's Environmental Health Study
Authors
Shin, JiyoungKim, Byung-MiHa, MinaPark, Hye-sookHong, Yun-ChulKim, YanghoKwon, Jung HyunHa, Eun-Hee
Ewha Authors
하은희박혜숙
SCOPUS Author ID
하은희scopus; 박혜숙scopus
Issue Date
2019
Journal Title
EPIDEMIOLOGY
ISSN
1044-3983JCR Link

1531-5487JCR Link
Citation
EPIDEMIOLOGY vol. 30, pp. S3 - S8
Keywords
Atopic dermatitisBirth cohortBlood mercuryChildhoodHeavy metal
Publisher
LIPPINCOTT WILLIAMS &

WILKINS
Indexed
SCIE; SSCI; SCOPUS WOS scopus
Document Type
Article
Abstract
Background: Atopic dermatitis is a chronic and relapsing inflammatory skin disease. Although mercury has been suggested as a risk factor, the underlying mechanism and the relationship between mercury and atopic dermatitis remains unclear. The objective of the present study was to investigate the relationship between mercury exposure and the presence of atopic dermatitis in early childhood. Methods: This study is part of the prospective Mothers and Children's Environmental Health cohort study. A total of 1,751 pregnant women were enrolled in Mothers and Children's Environmental Health. After delivery, children were followed up. Blood samples were collected and mothers were asked about the presence of atopic dermatitis in their children via a questionnaire at 6, 12, 24, 36, and 60 months of age. Results: After excluding participants who did not meet the inclusion criteria, a total of 1,061 mother-children pairs were included in the analysis. The geometric mean of mercury concentrations in cord blood was 5.1 mu g/L. In adjusted models, cord blood mercury exposure (odds ratio [OR] - 1.1; 95% confidence interval [CI] - 1.0, 1.2 at 12-24 months) and postnatal mercury exposure (OR - 1.2; 95% CI = 1.0,1.5 at 24-36 months, OR = 1.4; 95% CI = 1.1, 1.8 at 48-60 months) were associated with the presence of atopic dermatitis in children. Conclusions: Postnatal mercury exposure at 24 months of age increases the risk of atopic dermatitis in children.
DOI
10.1097/EDE.0000000000001002
Appears in Collections:
의과대학 > 의학과 > Journal papers
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