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Pathogenetic factors involved in recurrent pregnancy loss from multiple aspects

Title
Pathogenetic factors involved in recurrent pregnancy loss from multiple aspects
Authors
Pei C.-Z.Kim Y.J.Baek K.-H.
Ewha Authors
김영주
SCOPUS Author ID
김영주scopus
Issue Date
2019
Journal Title
Obstetrics and Gynecology Science
ISSN
2287-8572JCR Link
Citation
Obstetrics and Gynecology Science vol. 62, no. 4, pp. 212 - 223
Keywords
ProteomicsRecurrent miscarriageVitamin D
Publisher
Korean Society of Obstetrics and Gynecology
Indexed
SCOPUS; KCI scopus
Document Type
Review
Abstract
Recurrent pregnancy loss (RPL) is a common complication in obstetrics, affecting about 5% of women of childbearing age. An increase in the number of abortions results in escalation in the risk of miscarriage. Although concentrated research has identified numerous causes for RPL, about 50% of them remain unexplained. Pregnancy is a complex process, comprising fertilization, implantation, organ and tissue differentiation, and fetal growth, which is effectively controlled by a number of both maternal and fetal factors. An example is the immune response, in which T cells and natural killer cells participate, and inflammation mediated by tumor necrosis factor or colony-stimulating factor, which hinders embryo implantation. Furthermore, vitamin D affects glucose metabolism and inhibits embryonic development, whereas microRNA has a negative effect on the gene expression of embryo implantation and development. This review examines the causes of RPL from multiple perspectives, and focuses on the numerous factors that may result in RPL. © 2019 Korean Society of Obstetrics and Gynecology.
DOI
10.5468/ogs.2019.62.4.212
Appears in Collections:
의과대학 > 의학과 > Journal papers
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