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Artificial Control of Cell Signaling Using a Photocleavable Cobalt(III)–Nitrosyl Complex

Title
Artificial Control of Cell Signaling Using a Photocleavable Cobalt(III)–Nitrosyl Complex
Authors
Shin S.Choe J.Park Y.Jeong D.Song H.You Y.Seo D.Cho J.
Ewha Authors
유영민
SCOPUS Author ID
유영민scopus
Issue Date
2019
Journal Title
Angewandte Chemie - International Edition
ISSN
1433-7851JCR Link
Citation
Angewandte Chemie - International Edition vol. 58, no. 30, pp. 10126 - 10131
Keywords
cobalt(III)–nitrosyl complexkinase translocation reporternitric oxidephotolysissignal transduction
Publisher
Wiley-VCH Verlag
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Cells use gaseous molecules such as nitric oxide (NO) to transmit both intracellular and intercellular signals. In principle, the endogenous small molecules regulate physiological changes, but it is unclear how randomly diffusive molecules trigger and discriminate signaling programs. Herein, it is shown that gasotransmitters use time-dependent dynamics to discriminate the endogenous and exogenous inputs. For a real-time stimulation of cell signaling, we synthesized a photo-cleavable metal–nitrosyl complex, [CoIII(MDAP)(NO)(CH3CN)]2+ (MDAP=N,N′-dimethyl-2,11-diaza[3,3](2,6)pyridinophane), which can stably deliver and selectively release NO with fine temporal resolution in the cytosol, and used this to study the extracellular signal-regulated kinases (ERKs), revealing how cells use both exogenous and endogenous NO to disentangle cellular responses. This technique can be to understand how diverse cellular signaling networks are dynamically interconnected and also to control drug delivery systems. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI
10.1002/anie.201903106
Appears in Collections:
엘텍공과대학 > 화학신소재공학전공 > Journal papers
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