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2-(trimethylammonium)ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate enhances thrombopoietin-induced megakaryocytic differentiation and plateletogenesis

Title
2-(trimethylammonium)ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate enhances thrombopoietin-induced megakaryocytic differentiation and plateletogenesis
Authors
Kim, JusongJin, GuanghaiLee, JisuLee, KyeongBae, Yun SooKim, Jaesang
Ewha Authors
배윤수김재상
SCOPUS Author ID
배윤수scopus; 김재상scopus
Issue Date
2019
Journal Title
BMB REPORTS
ISSN
1976-6696JCR Link

1976-670XJCR Link
Citation
BMB REPORTS vol. 52, no. 7, pp. 434 - 438
Keywords
(R)-TEMOSPhoMegakaryocytePlateletThrombopoietin
Publisher
KOREAN SOCIETY BIOCHEMISTRY &

MOLECULAR BIOLOGY
Indexed
SCIE; SCOPUS; KCI WOS
Document Type
Article
Abstract
We have previously reported the effects of 2-(trimethylammonium)ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate [(R)-TEMOSPho], a synthetic phospholipid, on megakaryocytic differentiation of myeloid leukemia cells. Here, we demonstrate that (R)-TEMOSPho enhances megakaryopoiesis and plateletogenesis from primary hematopoietic stem cells (HSCs) induced by thrombopoietin (TPO). Specifically, we demonstrate at sub-saturation levels of TPO, the addition of (R)-TEMOSPho enhances differentiation and maturation of megakaryocytes (MKs) from murine HSCs derived from fetal liver. Furthermore, we show that production of platelets with (R)-TEMOSPho in combination with TPO is also more efficient than TPO alone and that platelets generated in vitro with these two agents are as functional as those from TPO alone. TPO can thus be partly replaced by or supplemented with (R)-TEMOSPho, and this in turn implies that (R)-TEMOSPho can be useful in efficient platelet production in vitro and potentially be a valuable option in designing cell-based therapy.
DOI
10.5483/BMBRep.2019.52.7.200
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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