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dc.contributor.author김형래-
dc.date.accessioned2019-08-22T16:30:03Z-
dc.date.available2019-08-22T16:30:03Z-
dc.date.issued2019-
dc.identifier.issn1042-8194-
dc.identifier.issn1029-2403-
dc.identifier.otherOAK-25248-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/251215-
dc.description.abstractAllogeneic hematopoietic stem cell transplantation (allo-HSCT) has been the only treatment option for acute myeloid leukemia (AML) refractory to induction chemotherapy, with only 10-20% of patients achieving long-term survival. Certain donor genotypes may confer leukemia-clearing effects after allo-HSCT. We performed whole-exome sequencing of five pairs of the germ lines in AML patients who achieved long-term remission after allo-HSCT and in their donors, and found two significant variants: EGFR c.2982C>T and CDH11 c.945G>A. To validate the protective effects of these leukemia-clearing genotypes (LCGs), AML patients who received allo-HSCT in a complete-remission status were also analyzed. Twenty-two of 96 donors (22.9%) had LCGs in their genomes, and overall survival was significantly longer in patients who received allo-HSCT from donors with germ-line LCGs (hazard ratio=0.47, 95% confidence interval=0.24-0.94, p=.033). These findings indicate that donor germ-line LCGs have phenotypically leukemia-clearing effects and are biomarkers for predicting clinical outcomes in allogeneic transplantation in AML patients.-
dc.languageEnglish-
dc.publisherTAYLOR &amp-
dc.publisherFRANCIS LTD-
dc.subjectDonor genotype-
dc.subjecthematopoietic stem cell transplantation-
dc.subjectacute myeloid leukemia-
dc.subjectwhole-exome sequencing-
dc.subjectsurvival-
dc.titleDiscovery of donor genotype associated with long-term survival of patients with hematopoietic stem cell transplantation in refractory acute myeloid leukemia-
dc.typeArticle-
dc.relation.issue7-
dc.relation.volume60-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1775-
dc.relation.lastpage1781-
dc.relation.journaltitleLEUKEMIA & LYMPHOMA-
dc.identifier.doi10.1080/10428194.2018.1542142-
dc.identifier.wosidWOS:000478841300022-
dc.author.googleOck, Chan-Young-
dc.author.googleSeo, Heewon-
dc.author.googleKim, Dae-Yoon-
dc.author.googleMin, Byung Joo-
dc.author.googlePark, Yoomi-
dc.author.googleCheong, Hyun Sub-
dc.author.googleKim, Hyung-Lae-
dc.author.googleSong, Eun-Young-
dc.author.googleKim, Inho-
dc.author.googleYoon, Sung-Soo-
dc.author.googleKim, Ju Han-
dc.author.googleKoh, Youngil-
dc.contributor.scopusid김형래(35278256500)-
dc.date.modifydate20190822104618-
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의과대학 > 의학과 > Journal papers
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