View : 33 Download: 0

Discovery of donor genotype associated with long-term survival of patients with hematopoietic stem cell transplantation in refractory acute myeloid leukemia

Title
Discovery of donor genotype associated with long-term survival of patients with hematopoietic stem cell transplantation in refractory acute myeloid leukemia
Authors
Ock, Chan-YoungSeo, HeewonKim, Dae-YoonMin, Byung JooPark, YoomiCheong, Hyun SubKim, Hyung-LaeSong, Eun-YoungKim, InhoYoon, Sung-SooKim, Ju HanKoh, Youngil
Ewha Authors
김형래
SCOPUS Author ID
김형래scopus
Issue Date
2019
Journal Title
LEUKEMIA & LYMPHOMA
ISSN
1042-8194JCR Link

1029-2403JCR Link
Citation
LEUKEMIA & LYMPHOMA vol. 60, no. 7, pp. 1775 - 1781
Keywords
Donor genotypehematopoietic stem cell transplantationacute myeloid leukemiawhole-exome sequencingsurvival
Publisher
TAYLOR &

FRANCIS LTD
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been the only treatment option for acute myeloid leukemia (AML) refractory to induction chemotherapy, with only 10-20% of patients achieving long-term survival. Certain donor genotypes may confer leukemia-clearing effects after allo-HSCT. We performed whole-exome sequencing of five pairs of the germ lines in AML patients who achieved long-term remission after allo-HSCT and in their donors, and found two significant variants: EGFR c.2982C>T and CDH11 c.945G>A. To validate the protective effects of these leukemia-clearing genotypes (LCGs), AML patients who received allo-HSCT in a complete-remission status were also analyzed. Twenty-two of 96 donors (22.9%) had LCGs in their genomes, and overall survival was significantly longer in patients who received allo-HSCT from donors with germ-line LCGs (hazard ratio=0.47, 95% confidence interval=0.24-0.94, p=.033). These findings indicate that donor germ-line LCGs have phenotypically leukemia-clearing effects and are biomarkers for predicting clinical outcomes in allogeneic transplantation in AML patients.
DOI
10.1080/10428194.2018.1542142
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE