Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.contributor.author | 이대기 | * |
dc.contributor.author | 박진희 | * |
dc.date.accessioned | 2019-08-22T16:30:02Z | - |
dc.date.available | 2019-08-22T16:30:02Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1226-3613 | * |
dc.identifier.other | OAK-25252 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/251211 | - |
dc.description.abstract | The scaffolding protein receptor for activated C-kinase 1 (RACK1) mediates receptor activator of nuclear factor κΒ ligand (RANKL)-dependent activation of p38 MAPK in osteoclast precursors; however, the role of RACK1 in mature osteoclasts is unclear. The aim of our study was to identify the interaction between RACK1 and c-Src that is critical for osteoclast function. A RACK1 mutant protein (mutations of tyrosine 228 and 246 residues to phenylalanine; RACK1 Y228F/Y246F) did not interact with c-Src. The mutant retained its ability to differentiate into osteoclasts; however, the integrity of the RANKL-mediated cytoskeleton, bone resorption activity, and phosphorylation of c-Src was significantly decreased. Importantly, lysine 152 (K152) within the Src homology 2 (SH2) domain of c-Src is involved in RACK1 binding. The c-Src K152R mutant (mutation of lysine 152 into arginine) impaired the resorption of bone by osteoclasts. These findings not only clarify the role of the RACK1-c-Src axis as a key regulator of osteoclast function but will also help to develop new antiresorption therapies to prevent bone loss-related diseases. © 2019, The Author(s). | * |
dc.language | English | * |
dc.publisher | Nature Publishing Group | * |
dc.title | RACK1 interaction with c-Src is essential for osteoclast function | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 51 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.journaltitle | Experimental and Molecular Medicine | * |
dc.identifier.doi | 10.1038/s12276-019-0285-4 | * |
dc.identifier.wosid | WOS:000479315900002 | * |
dc.identifier.scopusid | 2-s2.0-85069924639 | * |
dc.author.google | Park J.H. | * |
dc.author.google | Jeong E. | * |
dc.author.google | Lin J. | * |
dc.author.google | Ko R. | * |
dc.author.google | Kim J.H. | * |
dc.author.google | Yi S. | * |
dc.author.google | Choi Y. | * |
dc.author.google | Kang I.-C. | * |
dc.author.google | Lee D. | * |
dc.author.google | Lee S.Y. | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.contributor.scopusid | 이대기(37047040400) | * |
dc.contributor.scopusid | 박진희(57196405683;56593418700) | * |
dc.date.modifydate | 20240415140424 | * |