Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김휘영 | * |
dc.date.accessioned | 2019-07-29T16:31:06Z | - |
dc.date.available | 2019-07-29T16:31:06Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 0269-2813 | * |
dc.identifier.issn | 1365-2036 | * |
dc.identifier.other | OAK-22649 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/250290 | - |
dc.description.abstract | Background: Data are insufficient regarding the survival benefit of surveillance for hepatocellular carcinoma (HCC). Aim: To investigate the effectiveness of HCC surveillance in a hepatitis B-endemic population. Methods: This retrospective cohort study included 1402 consecutive patients who were newly diagnosed with HCC between 2005 and 2012 at a single tertiary hospital in Korea. The primary endpoint was overall survival. Lead-time and length-time biases were adjusted (sojourn time = 140 days) and sensitivity analyses were performed. Results: The most common aetiology was hepatitis B (80.4%). Cirrhosis was present in 78.2%. HCC was diagnosed during regular surveillance (defined as mean interval of ultrasonography <8 months, n = 834), irregular surveillance (n = 104) or non-surveillance (n = 464). Patients in the regular surveillance group were diagnosed at earlier stages ([very] early stage, 64.4%) than the irregular surveillance (40.4%) or nonsurveillance (26.9%) groups and had more chance for curative treatments (52.4%) than the irregular surveillance (39.4%) or nonsurveillance (23.3%) groups (all P < 0.001). Mortality risk was significantly lower in the regular surveillance group (adjusted hazard ratio [aHR], 0.69; 95% [CI], 0.57-0.83) but not in the irregular surveillance group (aHR, 0.94; 95% CI, 0.69-1.28) compared with the nonsurveillance group after adjusting for confounding factors and lead-time. When the subjects were restricted to cirrhotic patients or Child-Pugh class A/B patients, similar results were obtained for mortality risk reduction between groups. Conclusions: HCC surveillance was associated with longer survival owing to earlier diagnosis and curative treatment. Survival advantage was significant with regular surveillance but not with irregular surveillance. | * |
dc.language | English | * |
dc.publisher | WILEY | * |
dc.title | Intensity of surveillance for hepatocellular carcinoma determines survival in patients at risk in a hepatitis B-endemic area | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 47 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1490 | * |
dc.relation.lastpage | 1501 | * |
dc.relation.journaltitle | ALIMENTARY PHARMACOLOGY & THERAPEUTICS | * |
dc.identifier.doi | 10.1111/apt.14623 | * |
dc.identifier.wosid | WOS:000434038400007 | * |
dc.identifier.scopusid | 2-s2.0-85047793684 | * |
dc.author.google | Kim, H. Y. | * |
dc.author.google | Nam, J. Y. | * |
dc.author.google | Lee, J-H | * |
dc.author.google | Lee, H. A. | * |
dc.author.google | Chang, Y. | * |
dc.author.google | Lee, H. Y. | * |
dc.author.google | Cho, H. | * |
dc.author.google | Lee, D. H. | * |
dc.author.google | Cho, Y. Y. | * |
dc.author.google | Cho, E. J. | * |
dc.author.google | Yu, S. J. | * |
dc.author.google | Lee, J. M. | * |
dc.author.google | Kim, Y. J. | * |
dc.author.google | Yoon, J-H | * |
dc.contributor.scopusid | 김휘영(56493773500) | * |
dc.date.modifydate | 20240429140130 | * |