View : 151 Download: 0

Aminotransferase levels, body mass index, and the risk of diabetes: a prospective cohort study

Title
Aminotransferase levels, body mass index, and the risk of diabetes: a prospective cohort study
Authors
Song, Bo MiKim, Hyeon ChangKim, Dae JungAhn, Song VogueKim, Kyoung MinLee, Ju-MiKoh, Sang-BaekSuh, Il
Ewha Authors
안성복
Issue Date
2018
Journal Title
ANNALS OF EPIDEMIOLOGY
ISSN
1047-2797JCR Link

1873-2585JCR Link
Citation
ANNALS OF EPIDEMIOLOGY vol. 28, no. 10, pp. 675 - 680
Keywords
ALTASTObesityDiabetesKorean
Publisher
ELSEVIER SCIENCE INC
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Purpose: To investigate whether the relationship between body mass index (BMI) and incident diabetes is modified by different alanine or aspartate aminotransferases (ALT or AST) levels. Methods: We carried out an analysis of 6484 participants aged 40 years or older using data from the Korean Genome Epidemiology Study. The serum aminotransferase levels were stratified into low and high groups according to the median values and classified into three groups: both low, either high, and both high. To assess the association between BMI and incident diabetes according to the serum aminotransferase levels, multiple logistic regression models were used. Results: In participants with high levels of both ALT and AST, compared with the first BMI quartile, the adjusted odds ratios for incident diabetes of the second, third, and fourth BMI quartiles were 1.72 (95% confidence interval, 0.84-3.55), 2.19 (1.11-4.33), and 3.08 (1.60-5.90), respectively (P trend <.001). In participants with either high ALT or AST, the adjusted odds ratios were 3.58 (1.23-10.41), 2.65 (0.90 7.76), and 5.28 (1.86-15.02), respectively (P trend =.005). However, in participants with both low ALT and AST levels, high BMI was not independently associated with the risk of incident diabetes. Conclusions: There was a strong association between BMI and incident diabetes among individuals with high aminotransferase levels, whereas no association was observed among those with low aminotransferase levels. (C) 2018 Elsevier Inc. All rights reserved.
DOI
10.1016/j.annepidem.2018.07.009
Appears in Collections:
신산업융합대학 > 융합보건학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE