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Progress toward a group B streptococcal vaccine
- Title
- Progress toward a group B streptococcal vaccine
- Authors
- Song, Joon Young; Lim, Jae Hyang; Lim, Sangyong; Yong, Zhi; Seo, Ho Seong
- Ewha Authors
- 임재향
- SCOPUS Author ID
- 임재향
- Issue Date
- 2018
- Journal Title
- HUMAN VACCINES & IMMUNOTHERAPEUTICS
- ISSN
- 2164-5515
2164-554X
- Citation
- HUMAN VACCINES & IMMUNOTHERAPEUTICS vol. 14, no. 11, pp. 2669 - 2681
- Keywords
- group B Streptococcus; maternal immunization; Streptococcus agalactiae; vaccine
- Publisher
- TAYLOR &
FRANCIS INC
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Streptococcus agalactiae (group B Streptococcus, GBS) is a leading cause of severe invasive disease in neonate, elderly, and immunocompromised patients worldwide. Despite recent advances in the diagnosis and intrapartum antibiotic prophylaxis (IAP) of GBS infections, it remains one of the most common causes of neonatal morbidity and mortality, causing serious infections. Furthermore, recent studies reported an increasing number of GBS infections in pregnant women and elderly. Although IAP is effective, it has several limitations, including increasing antimicrobial resistance and late GBS infection after negative antenatal screening. Maternal immunization is the most promising and effective countermeasure against GBS infection in neonates. However, no vaccine is available to date, but two types of vaccines, protein subunit and capsular polysaccharide conjugate vaccines, were investigated in clinical trials. Here, we provide an overview of the GBS vaccine development status and recent advances in the development of immunoassays to evaluate the GBS vaccine clinical efficacy.
- DOI
- 10.1080/21645515.2018.1493326
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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Progress toward a group B streptococcal vaccine.pdf(1.65 MB)
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