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dc.contributor.author한평림-
dc.contributor.author김윤근-
dc.date.accessioned2019-07-29T16:30:06Z-
dc.date.available2019-07-29T16:30:06Z-
dc.date.issued2019-
dc.identifier.issn1226-2560-
dc.identifier.issn2093-8144-
dc.identifier.otherOAK-25150-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/250195-
dc.description.abstractGut microbiota play a role in regulating mental disorders, but the mechanism by which gut microbiota regulate brain function remains unclear. Gram negative and positive gut bacteria release membrane-derived extracellular vesicles (EVs), which function in microbiota-host intercellular communication. In the present study, we investigated whether Lactobacillus plantarum derived EVs (L-EVs) could have a role in regulating neuronal function and stress-induced depressive-like behaviors. HT22 cells treated with the stress hormone glucocorticoid (GC; corticosterone) had reduced expression of Bdnf and Sirt1, whereas L -EV treatment reversed GC-induced decreased expression of Bdnf and Sirt1. The siRNA-mediated knockdown of Sirt1 in HT22 cells decreased Bdnf4, a splicing variant of Bdnf, and Creb expression, suggesting that Sirt1 plays a role in L -EV-induced increase of BDNF and CREB expression. Mice exposed to restraint for 2-h daily for 14 days (CRST) exhibited depressive-like behaviors, and these CRST-treated mice had reduced expression of Bdnf and Nt4/5 in the hippocampus. In contrast, L-EV injection prior to each restraint treatment blocked the reduced expression of Bdnf and Nt4/5, and stress-induced depressive-like behaviors. Furthermore, L-EV treatment in CRST-treated mice also rescued the reduced expression of Bdnf, and blocked stress-induced depressive-like behaviors. These results suggest that Lactobacillus derived EVs can change the expression of neurotropic factors in the hippocampus and afford antidepressant-like effects in mice with stress-induced depression.-
dc.languageEnglish-
dc.publisherKOREAN SOC BRAIN &amp-
dc.publisherNEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE-
dc.subjectExtracellular vesicles-
dc.subjectLactobacillus plantarum-
dc.subjectBDNF-
dc.subjectAntidepressant-like effects-
dc.titleExtracellular Vesicles Derived from Lactobacillus plantarum Increase BDNF Expression in Cultured Hippocampal Neurons and Produce Antidepressant-like Effects in Mice-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume28-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage158-
dc.relation.lastpage171-
dc.relation.journaltitleEXPERIMENTAL NEUROBIOLOGY-
dc.identifier.doi10.5607/en.2019.28.2.158-
dc.identifier.wosidWOS:000468151200004-
dc.author.googleChoi, Juli-
dc.author.googleKim, Yoon-Keun-
dc.author.googleHan, Pyung-Lim-
dc.contributor.scopusid한평림(7201947605)-
dc.contributor.scopusid김윤근(56289306900;7410211755)-
dc.date.modifydate20190729150444-
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일반대학원 > 뇌·인지과학과 > Journal papers
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