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A Double-Blind, Randomized, Placebo-Controlled Crossover Clinical Study of the Effects of Alpha-s1 Casein Hydrolysate on Sleep Disturbance
- Title
- A Double-Blind, Randomized, Placebo-Controlled Crossover Clinical Study of the Effects of Alpha-s1 Casein Hydrolysate on Sleep Disturbance
- Authors
- Kim, Hyeon Jin; Kim, Jiyeon; Lee, Seungyeon; Kim, Bosil; Kwon, Eunjin; Lee, Jee Eun; Chun, Min Young; Lee, Chan Young; Boulier, Audrey; Oh, Seikwan; Lee, Hyang Woon
- Ewha Authors
- 오세관; 이향운; 권은진; 김현진
- SCOPUS Author ID
- 오세관; 이향운; 권은진; 김현진
- Issue Date
- 2019
- Journal Title
- NUTRIENTS
- ISSN
- 2072-6643
- Citation
- NUTRIENTS vol. 11, no. 7
- Keywords
- alpha-s1 casein hydrolysate; Lactium (R); nutritional supplements; clinical trial; sleep disturbance; insomnia; sleep quality
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- This study evaluated the effects of alpha-s1 casein hydrolysate (ACH; Lactium (R)) on the subjective and objective sleep profiles of a community-based sample of Koreans with poor sleep quality. We performed a double-blind, randomized crossover trial with 48 participants (49.0 +/- 1.7 years old, 65% female) who exhibited a mild to moderate degree of sleep disturbance. Either ACH or placebo was administered for the initial four weeks, and the counterpart was administered in precisely the same manner after a four-week washout period. Sleep disturbance scales, daytime functioning, and psychiatric aspects showed a similar tendency to improve during both ACH and placebo phases without significant group differences. Overall perceived sleep profiles in sleep diaries were significantly improved during the ACH phase, represented by increased total sleep time and sleep efficiency (SE), as well as decreased sleep latency and wake after sleep onset (WASO). Interestingly, actigraphy demonstrated significantly increased SE after continuous use of ACH for four weeks, clearly more improved when compared to two weeks of use. The polysomnography measures showed a similar tendency without statistically significant group differences. Our findings suggest that refined ACH was well tolerated and could improve sleep quality, with possible cumulative beneficial effects with long-term administration.
- DOI
- 10.3390/nu11071466
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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nutrients-11-01466-v2.pdf(786.64 kB)
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