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Plasma Klotho concentrations predict functional outcome at three months after acute ischemic stroke patients

Title
Plasma Klotho concentrations predict functional outcome at three months after acute ischemic stroke patients
Authors
Lee, Jun-BeomWoo, Ho GeolChang, YoonkyungJin, Yoon MiJo, InhoKim, JinkwonSong, Tae-Jin
Ewha Authors
조인호송태진장윤경우호걸
SCOPUS Author ID
조인호scopus; 송태진scopus
Issue Date
2019
Journal Title
ANNALS OF MEDICINE
ISSN
0785-3890JCR Link

1365-2060JCR Link
Citation
ANNALS OF MEDICINE vol. 51, no. 3-4, pp. 262 - 269
Keywords
Klothofibroblast growth factor 23strokefunctional outcome
Publisher
TAYLOR &

FRANCIS LTD
Indexed
SCI; SCIE; SCOPUS WOS
Document Type
Article
Abstract
Background: The Klotho protects the cardiovascular system by protecting against cell apoptosis, inhibiting the production of reactive oxygen species, and modulating inflammation. We aimed to investigate relationship of plasma Klotho concentrations with functional outcome at 3 months after acute cerebral infarction. Methods: We prospectively enrolled 262 first-ever acute cerebral infarction patients from whom a blood sample was acquired within 24 h of admission. An enzyme-linked immunosorbent assay was used for evaluating plasma Klotho concentration. Functional outcome on admission and three months was evaluated. Results: Of the 262 patients, 152 (58.0%) were men. The mean age of these patients was 64.7 years. The mean +/- standard deviation of plasma Klotho concentrations was 312.7 +/- 153.3 pg/mL. As opposed to patients with good outcome, plasma Klotho levels were lower in the poor outcome group (207.8 +/- 96.2 vs. 342.5 +/- 153.5 pg/mL, p = .001). In multivariate analysis, increased plasma Klotho concentrations were independently associated with good functional outcome (Odds ratio: 2.42, 95% confidence interval: 1.45-4.04, p < .001). Conclusions: Increased plasma Klotho concentrations were associated with good functional outcome in patients with acute ischemic stroke. We attribute these associations to the pleiotropic effects of Klotho in stroke and vascular diseases.Key message Increased plasma Klotho concentrations were associated with good functional outcome in patients with acute ischemic stroke.
DOI
10.1080/07853890.2019.1617434
Appears in Collections:
의과대학 > 의학과 > Journal papers
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