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The Benefit of Post-Mastectomy Radiotherapy in ypN0 Patients after Neoadjuvant Chemotherapy According to Molecular Subtypes

Title
The Benefit of Post-Mastectomy Radiotherapy in ypN0 Patients after Neoadjuvant Chemotherapy According to Molecular Subtypes
Authors
Cho, Won KyungPark, WonChoi, Doo HoKim, Yong BaeKim, Jin HoKim, Su SsanKim, KyuboKim, Jin HeeAhn, Sung-JaLee, Sun YoungLee, JeongshimKim, Sang-WonKwon, JeannyAhn, Ki Jung
Ewha Authors
김규보
SCOPUS Author ID
김규보scopus
Issue Date
2019
Journal Title
JOURNAL OF BREAST CANCER
ISSN
1738-6756JCR Link

2092-9900JCR Link
Citation
JOURNAL OF BREAST CANCER vol. 22, no. 2, pp. 285 - 296
Keywords
Breast neoplasmsMastectomyNeoadjuvant treatmentRadiotherapy
Publisher
KOREAN BREAST CANCER SOC
Indexed
SCIE; SCOPUS; KCI WOS
Document Type
Article
Abstract
Purpose: The benefit of post-mastectomy radiation therapy (PMRT) in patients with breast cancer who achieve ypN0 following neoadjuvant chemotherapy (NAC) has not yet been established. This study aimed to identify the role of PMRT in patients who achieve ypN0 according to molecular subtype. Methods: We identified patients initially suspected with axillary disease who achieved ypN0 following NAC. From 13 institutions of the Korean Radiation Oncology Group between 2005 and 2011, a total of 189 patients were included in the analysis. Effects of PMRT on loco-regional control (LRC), disease-free survival (DFS), and overall survival (OS) were evaluated for different molecular subtypes. Results: In all patients, the prognostic effect of PMRT on LRC, DFS, or OS was not significant. Subgroups analysis showed that the effect of PMRT on LRC was different according to molecular subtype (p for interaction = 0.019). PMRT was associated with greater LRC in the luminal subtype (p = 0.046), but not in other subtypes. Conclusion: In patients who achieve ypN0 following NAC and mastectomy, PMRT shows no additional survival benefits for any molecular subtype.
DOI
10.4048/jbc.2019.22.e25
Appears in Collections:
의과대학 > 의학과 > Journal papers
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