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Effects of Prenatal Growth Status on Subsequent Childhood Renal Function Related to High Blood Pressure

Title
Effects of Prenatal Growth Status on Subsequent Childhood Renal Function Related to High Blood Pressure
Authors
Park, BohyunLee, Jung WonKim, Hae SoonPark, Eun AeCho, Su JinPark, Hyesook
Ewha Authors
박은애김혜순박혜숙조수진박보현이정원
SCOPUS Author ID
박은애scopus; 김혜순scopus; 박혜숙scopus; 조수진scopus; 박보현scopus; 이정원scopus
Issue Date
2019
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
1011-8934JCR Link

1598-6357JCR Link
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE vol. 34, no. 25
Keywords
ChildRenal InsufficiencyPremature BirthLow Birth WeightBlood Pressure
Publisher
KOREAN ACAD MEDICAL SCIENCES
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
Background: Hypertension is one of the major causes of chronic diseases. The effect on high blood pressure (BP) with fetal growth restriction is now well-established. Recent studies suggest that a reduced number of nephrons programmed during the intrauterine period contribute to a subsequently elevated BP, due to a permanent nephron deficit. However, few studies have examined this in children. We investigated the effects of low birth weight (LBW) and preterm birth on the renal function markers related to a high BP in childhood. Methods: We used data from 304 children aged 7-12 years who participated in the 2014 Ewha Birth and Growth Cohort survey in Korea. We assessed the serum uric acid, cystatin C, blood urea nitrogen (BUN), creatinine levels, and the estimated glomerular filtration rate (eGFR) in childhood. Anthropometric characteristics, BP in childhood, birth weight and gestational age were collected. Results: The serum uric acid was significantly higher in LBW children (4.0 mg/dL) than in normal birth weight children (3.7 mg/dL). The cystatin C levels were highest among children who were very preterm (0.89 mg/dL) compared with those who were not (preterm, 0.84 mg/dL; normal, 0.81 mg/dL), although the result was only borderline significant (P for trend = 0.06). Decreased birth weight was found to be significantly associated with an increased serum BUN level in childhood. In the analysis of the effects of renal function on BP, subjects with an eGFR lower than the median value had a significantly higher diastolic BP in childhood (difference = 2.4 mmHg; P< 0.05). Conclusion: These findings suggest that LBW and preterm birth are risk factors for increased serum levels of renal function markers in childhood. Reduced eGFR levels were significantly associated with elevated diastolic BP in childhood. It is necessary to identify vulnerable individuals during their life and intervene appropriately to reduce the risk of an increased BP in the future.
DOI
10.3346/jkms.2019.34.e174
Appears in Collections:
의과대학 > 의학과 > Journal papers
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