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Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment
- Title
- Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment
- Authors
- Park, Jinse; Kim, Si-Eun; Kim, Eun-Joo; Lee, Byung In; Jeong, Jee Hyang; Na, Hae Ri; Choi, Seong Hye; Kang, Do-Young; Park, Kyung Won
- Ewha Authors
- 정지향
- SCOPUS Author ID
- 정지향
- Issue Date
- 2019
- Journal Title
- CLINICAL INTERVENTIONS IN AGING
- ISSN
- 1178-1998
- Citation
- CLINICAL INTERVENTIONS IN AGING vol. 14, pp. 1167 - 1175
- Keywords
- mild cognitive impairment; cognitive training; brain PET
- Publisher
- DOVE MEDICAL PRESS LTD
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Purpose: We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI). Patients and methods: Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks. Results: The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed. Conclusion: The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.
- DOI
- 10.2147/CIA.S200269
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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