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Nationwide antibiotic resistance mapping of Helicobacter pylori in Korea: A prospective multicenter study
- Title
- Nationwide antibiotic resistance mapping of Helicobacter pylori in Korea: A prospective multicenter study
- Authors
- Lee J.H.; Ahn J.Y.; Choi K.D.; Jung H.-Y.; Kim J.M.; Baik G.H.; Kim B.-W.; Park J.C.; Jung H.-K.; Cho S.J.; Shin C.M.; Choi Y.J.; Lee S.H.; Kim J.H.; Lee W.S.; Sung J.K.; Chung J.-W.; Cheung D.Y.; Lee H.; Min Y.W.; Kim J.J.; Kim S.Y.; Korean College of Helicobacter; Upper Gastrointestinal Research
- Ewha Authors
- 정혜경
- SCOPUS Author ID
- 정혜경
- Issue Date
- 2019
- Journal Title
- Helicobacter
- ISSN
- 1083-4389
- Citation
- Helicobacter vol. 24, no. 4
- Keywords
- antibiotics; Helicobacter pylori; Korea; resistance
- Publisher
- Blackwell Publishing Ltd
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Introduction: The eradication rates for Helicobacter pylori have decreased in Korea although the prevalence of this bacterium has also decreased. Antibiotic resistance is likely to be a crucial factor in H. pylori eradication success, and we therefore mapped these resistance patterns nationwide in Korea. Materials and Methods: Five hundred and ninety adult subjects were prospectively enrolled from 2017 to 2018 from 15 centers across six geographic areas of Korea. A total of 580 biopsy tissues had been sampled from these patients during an upper endoscopy and were frozen at −80°C and delivered to a central laboratory. The agar dilution method was used to determine the minimum inhibitory concentration of amoxicillin, clarithromycin, metronidazole, tetracycline, ciprofloxacin, and levofloxacin for each H. pylori isolate. Results: The culture success rate was 60.2% (349/580). Resistance rates against clarithromycin, metronidazole, amoxicillin, tetracycline, levofloxacin, and ciprofloxacin were 17.8%, 29.5%, 9.5%, 0%, 37.0%, and 37.0%, respectively. The geographic distribution of metronidazole and quinolone resistance was highly variable. Some subjects had multiple H. pylori strains in the antrum and body of the stomach and showed a heterogeneous resistance profile between these anatomic areas. The H. pylori multidrug resistance (MDR) rate was 25.2% (88/349) among amoxicillin, clarithromycin, metronidazole, tetracycline, and quinolone and 11.2% (39/349) among four of these major antibiotics except for quinolone. The Seoul and Chungcheong areas showed a relatively lower MDR rate. Conclusion: The antibiotic resistance of H. pylori differs by drug and geographic area in Korea. Detailed nationwide antibiotic resistance mapping is needed to develop an effective H. pylori eradication strategy. © 2019 John Wiley & Sons Ltd
- DOI
- 10.1111/hel.12592
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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