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Is Primary Androgen Deprivation Therapy a Suitable Option for Asian Patients With Prostate Cancer Corn red With Radical Prostatectomy?

Title
Is Primary Androgen Deprivation Therapy a Suitable Option for Asian Patients With Prostate Cancer Corn red With Radical Prostatectomy?
Authors
Ha, U-SynChoi, Jin BongShim, Jung ImKang, MinjooPark, EunjungKang, ShinheePark, JooyeonYang, JangmiChoi, InsunAhn, JeonghoonKwak, CheolJeong, Chang WookKim, Choung SooByun, Seok-SooSeo, Seong IlLee, Hyun MooLee, Seung-JuLee, Seung HwanChung, Byung HaLee, Ji Youl
Ewha Authors
안정훈
SCOPUS Author ID
안정훈scopus
Issue Date
2019
Journal Title
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
ISSN
1540-1405JCR Link

1540-1413JCR Link
Citation
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK vol. 17, no. 5, pp. 441 - 449
Publisher
HARBORSIDE PRESS
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Background: We conducted a comparative survival analysis between primary androgen deprivation therapy (PADT) and radical prostatectomy (RP) based on nationwide Korean population data that included all patients with prostate cancer. Materials and Methods: This study enrolled 4,538 patients with prostate cancer from the National Health Insurance Service (NHIS) database linked with Korean Central Cancer Registry data who were treated with PADT or RP between January 1, 2007, and December 31, 2014. Kaplan-Meier and multivariate survival analyses stratified by stage (localized and locally advanced) and age (<75 and >= 75years) were performed using a Cox proportional hazards model to evaluate treatment effects. Results: Among 18,403 patients from the NHIS database diagnosed with prostate cancer during the study period, 4,538 satisfied inclusion criteria and were included in the analyses. Of these, 3,136 and 1,402 patients underwent RP or received PADT, respectively. Risk of death was significantly increased for patients who received PADT compared with those who underwent RP in the propensity score-matched cohort. In subgroup analyses stratified by stage and age, in every subgroup, patients who received PADT had a significantly increased risk of death compared with those who underwent RP. In particular, a much greater risk was observed for patients with locally advanced prostate cancer. Conclusions: Based on a nationwide survival analysis of nonmetastatic prostate cancer, this study provides valuable clinical implications that favor RP over PDAT for treatment of Asian populations. However, the possibility that survival differences have been overestimated due to not accounting for potential confounding characteristics must be considered.
DOI
10.6004/jnccn.2018.7265
Appears in Collections:
신산업융합대학 > 융합보건학과 > Journal papers
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