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Radiation therapy for extrahepatic bile duct cancer: Current evidences and future perspectives

Title
Radiation therapy for extrahepatic bile duct cancer: Current evidences and future perspectives
Authors
Koo, TaeryoolPark, Hae JinKim, Kyubo
Ewha Authors
김규보
SCOPUS Author ID
김규보scopus
Issue Date
2019
Journal Title
WORLD JOURNAL OF CLINICAL CASES
ISSN
2307-8960JCR Link
Citation
WORLD JOURNAL OF CLINICAL CASES vol. 7, no. 11, pp. 1242 - 1252
Keywords
Extrahepatic bile duct cancerPatterns of failureAdjuvant radiotherapyDefinitive radiotherapyPalliative radiotherapyBiliary stent
Publisher
BAISHIDENG PUBLISHING GROUP INC
Indexed
SCIE WOS
Document Type
Review
Abstract
Extrahepatic bile duct cancer (EBDC) is a rare malignancy that involves neoplastic changes extending from both hepatic ducts to the common bile duct. The treatment of choice is surgical resection, but the predominant pattern of initial treatment failure is locoregional recurrence. Accordingly, adjuvant radiotherapy has been administered after surgical resection based on these rationales. At this time, there is minimal evidence supporting adjuvant radiotherapy, because there have been no phase III trials evaluating its benefit. Relatively small retrospective studies have tried to compare outcomes associated with EBDC treated with or without radiotherapy. We aimed to review studies investigating adjuvant radiotherapy for resected EBDC. Because less than one-third of EBDC cases are amenable to curative resection at diagnosis, other locoregional treatment modalities need to be considered, including radiotherapy. The next aim of this review was to summarize reports of definitive radiotherapy for unresectable EBDC. Patients with advanced EBDC often experience biliary obstruction, which can lead to jaundice and progress to death. Biliary stent insertion is an important palliative procedure, but stents are prone to occlusion after subsequent ingrowth of the EBDC. Radiotherapy can be effective for maintaining the patency of inserted stents. We also reviewed the benefit of palliative radiotherapy combined with the biliary stent. insertion. Lastly, we discuss the existing gaps in the evidence supporting radiotherapy in the management of EBDC.
DOI
10.12998/wjcc.v7.i11.1242
Appears in Collections:
의과대학 > 의학과 > Journal papers
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