View : 71 Download: 0
Radiation therapy for extrahepatic bile duct cancer: Current evidences and future perspectives
- Radiation therapy for extrahepatic bile duct cancer: Current evidences and future perspectives
- Koo, Taeryool; Park, Hae Jin; Kim, Kyubo
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- WORLD JOURNAL OF CLINICAL CASES
- WORLD JOURNAL OF CLINICAL CASES vol. 7, no. 11, pp. 1242 - 1252
- Extrahepatic bile duct cancer; Patterns of failure; Adjuvant radiotherapy; Definitive radiotherapy; Palliative radiotherapy; Biliary stent
- BAISHIDENG PUBLISHING GROUP INC
- Document Type
- Extrahepatic bile duct cancer (EBDC) is a rare malignancy that involves neoplastic changes extending from both hepatic ducts to the common bile duct. The treatment of choice is surgical resection, but the predominant pattern of initial treatment failure is locoregional recurrence. Accordingly, adjuvant radiotherapy has been administered after surgical resection based on these rationales. At this time, there is minimal evidence supporting adjuvant radiotherapy, because there have been no phase III trials evaluating its benefit. Relatively small retrospective studies have tried to compare outcomes associated with EBDC treated with or without radiotherapy. We aimed to review studies investigating adjuvant radiotherapy for resected EBDC. Because less than one-third of EBDC cases are amenable to curative resection at diagnosis, other locoregional treatment modalities need to be considered, including radiotherapy. The next aim of this review was to summarize reports of definitive radiotherapy for unresectable EBDC. Patients with advanced EBDC often experience biliary obstruction, which can lead to jaundice and progress to death. Biliary stent insertion is an important palliative procedure, but stents are prone to occlusion after subsequent ingrowth of the EBDC. Radiotherapy can be effective for maintaining the patency of inserted stents. We also reviewed the benefit of palliative radiotherapy combined with the biliary stent. insertion. Lastly, we discuss the existing gaps in the evidence supporting radiotherapy in the management of EBDC.
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.