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Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease

Title
Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease
Authors
Kim, Sang YoonJung, Hye-KyungLim, JiyoungKim, Tae OhChoe, A. ReumTae, Chung HyunShim, Ki-NamMoon, Chang MoKim, Seong-EunJung, Sung-Ae
Ewha Authors
정성애정혜경심기남김성은문창모태정현
SCOPUS Author ID
정성애scopus; 정혜경scopus; 심기남scopus; 김성은scopus; 문창모scopus; 태정현scopusscopus
Issue Date
2019
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
1011-8934JCR Link

1598-6357JCR Link
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE vol. 34, no. 21
Keywords
Gastro-Esophageal Reflux DiseaseGender DistributionMenopausePrevalenceRisk Factors
Publisher
KOREAN ACAD MEDICAL SCIENCES
Indexed
SCIE; SCOPUS; KCI WOS
Document Type
Article
Abstract
Background: Gender-related factors might play an important role in the development of reflux esophagitis (RE) and symptomatic gastro-esophageal reflux disease (GERD). We aimed to evaluate the prevalence and risk factors for RE and symptomatic GERD and determine whether gender specific differences exist. Methods: This study was conducted on a health cohort consisting of 10,158 participants who underwent comprehensive health screening. Lifestyles and gastrointestinal symptoms were investigated using a self-reported structured questionnaire. Questionnaires about menstrual status were added for the women. Results: The prevalence of RE in men was significantly higher than that in women (10.6% vs. 2.0%, P< 0.001); however, symptomatic GERD showed predominance in women (6.2% vs. 2.5%, P< 0.001). Although the prevalence of RE gradually increased with the duration of menopause stratified by decade (P= 0.007), that of symptomatic GERD rapidly increased across the menopausal transit in women. Apart from common risk factors of obesity and current smoking for RE, over 70 years of age in women and hiatal hernia and hypertriglyceridemia in men were significant risk factors. In symptomatic GERD, high somatization was a common risk factor. Excessive alcohol drinking was a significant risk factor in men, but not in women. Conclusion: This study showed a predominance of RE in men, but a predominance of symptomatic GERD in women. In women, dynamic increase in the prevalence of GERD is closely related to the menopause conditions and its duration. There are specific risk factors for RE and symptomatic GERD according to gender differences.
DOI
10.3346/jkms.2019.34.e158
Appears in Collections:
의과대학 > 의학과 > Journal papers
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