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Alleviation of Atopic Dermatitis Lesions by a Benzylideneacetophenone Derivative via the MAPK Signaling Pathway
- Alleviation of Atopic Dermatitis Lesions by a Benzylideneacetophenone Derivative via the MAPK Signaling Pathway
- Sur, Bongjun; Kang, Seungmin; Kim, Mijin; Oh, Seikwan
- Ewha Authors
- 오세관; 서봉준
- SCOPUS Author ID
- Issue Date
- Journal Title
- INFLAMMATION vol. 42, no. 3, pp. 1093 - 1102
- atopic dermatitis; benzylideneacetophenone derivative; trimellitic anhydride; interleukin-4; mitogen-activated protein kinase
- SPRINGER/PLENUM PUBLISHERS
- SCIE; SCOPUS
- Document Type
- This experiment was conducted to investigate the effects of a benzylideneacetophenone derivative ((2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one (JC3)) on trimellitic anhydride (TMA)-induced atopic dermatitis (AD)-like symptoms in mice. To induce AD, the dorsal skins of mice were treated with 5% TMA on day 0 and both ears were treated with 5% TMA on day 5 and with 2% TMA from day 6 to day 14. JC3 (1, 5, 10mg/kg, i.p.) was treated once daily from day 9 to day 14 before TMA treatment. Histological analysis was performed and auricular lymph node weights, ear thicknesses, skin water contents, scratching behaviors, and serum immunoglobulin (IgE) and IFN-, and interleukin-4 (IL-4) levels in serum and ear tissues were determined. In addition, the anti-AD activity of JC3 was investigated on phorbol 12-myristate 13-acetate (PMA)-stimulated human mast cells (HMC-1 cells) derived from patients. Levels of TNF-, IL-4, and mitogen-activated protein kinase (MAPK) were investigated after treating cultured cells with JC3. Treating mice with JC3 (10mg/kg) significantly decreased ear thicknesses, lymph node weights, skin scores, skin water contents, scratching behavior, and IFN-, IL-4 cytokine levels, and serum IgE levels. Moreover, treatment with JC3 (10mg/kg) significantly decreased serum and ear tissues levels of IFN- and IL-4 in AD mice. Furthermore, treatment with JC3 at 10g/ml reduced TNF- and IL-4 levels and decreased MAPK phosphorylation in the HMC-1 cells. The results of this study provide a molecular basis for developing new therapeutics for the treatment of various inflammatory diseases, such as, eczema, asthma, and AD.
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