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Blood amyloid- oligomerization associated with neurodegeneration of Alzheimer's disease

Title
Blood amyloid- oligomerization associated with neurodegeneration of Alzheimer's disease
Authors
Youn, Young ChulKang, SungminSuh, JeewonPark, Young HoKang, Min JuPyun, Jung-MinChoi, Seong HyeJeong, Jee HyangPark, Kyung WonLee, Ho-WonAn, Seong Soo A.Dominguez, Jacqueline C.Kim, SangYun
Ewha Authors
정지향
SCOPUS Author ID
정지향scopus
Issue Date
2019
Journal Title
ALZHEIMERS RESEARCH & THERAPY
ISSN
1758-9193JCR Link
Citation
ALZHEIMERS RESEARCH & THERAPY vol. 11
Keywords
OligomerizationBlood-based biomarkerAmyloidOligomerMultimer detection systemVoxel-based morphometryMultimer detection system-oligomeric A
Publisher
BMC
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
IntroductionOligomeric amyloid-ss is a major toxic species associated with Alzheimer's disease pathogenesis. Methods used to measure oligomeric amyloid- in the blood have increased in number in recent years. The Multimer Detection System-Oligomeric Amyloid- (MDS-OA) is a specific method to measure oligomerization tendencies in the blood. The objective of this study was to determine the association between amyloid-ss oligomerization in the plasma and structural changes of the brain.MethodsWe studied 162 subjects composed of 92 community-based normal healthy subjects, 17 with subjective cognitive decline, 14 with mild cognitive impairment and 39 with Alzheimer's disease dementia. All subjects underwent MDS-OA and three-dimensional T1 magnetic resonance imaging. To determine the structural changes of the brain that are statistically correlated with MDS-OA level, we used voxel-based morphometry with corrections for age and total intracranial volume covariates.ResultsWe found brain volume reduction in the bilateral temporal, amygdala, parahippocampal and lower parietal lobe and left cingulate and precuneus regions (family-wise error, p<0.05). Reduction was also found in white matter in proximity to the left temporal and bilateral lower parietal lobes and posterior corpus callosum (family-wise error, p<0.05). Brain volume increment was not observed in any regions within grey or white matter.DiscussionFindings suggest that substantial correlation exists between amyloid ss oligomerization in the blood and brain volume reduction in the form of Alzheimer's disease despite of uncertainty in the casual relationship.
DOI
10.1186/s13195-019-0499-7
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의과대학 > 의학과 > Journal papers
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