Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 송태진 | * |
dc.date.accessioned | 2019-06-04T16:30:06Z | - |
dc.date.available | 2019-06-04T16:30:06Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1932-6203 | * |
dc.identifier.other | OAK-24848 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/249907 | - |
dc.description.abstract | Stroke patients are at high risk of developing pneumonia, which is major cause of post stroke mortality. Proton pump inhibitors and H-2 receptor antagonists are anti-ulcer drugs, which may predispose to the development of pneumonia by suppression of the gastric acid with bactericidal activity. Unlike proton pump inhibitors and H-2 receptor antagonists, mucoprotective agents have gastroprotective effects with no or less anti-acid property. We aimed to investigate effects of the acid-suppressive medications (proton pump inhibitors and H-2 receptor antagonists) and mucoprotective agents on risk for post-stroke pneumonia using the National Health Insurance Service-National Sample Cohort in Korea. This retrospective cohort study included 8,319 patients with acute ischemic stroke. Use of proton pump inhibitors, H-2 receptor antagonists, and mucoprotective agents (rebamipide, teprenone, irsogladine, ecabet, polaprezinc, sofalcone, sucralfate, and misoprostol) after stroke were determined based on the prescription records, which were treated as time-dependent variables. Primary outcome was the development of post-stroke pneumonia. During the mean follow-up period of 3.95 years after stroke, 2,035 (24.5%) patients had pneumonia. In the multivariate time-dependent Cox regression analyses (adjusted hazard ratio [95% confidence interval]), there was significantly increased risk for pneumonia with use of proton pump inhibitors (1.56 [1.24-1.96]) and H-2 receptor antagonists (1.40 [1.25-1.58]). In contrast to the proton pump inhibitors and H-2 receptor antagonists, use of mucoprotective agents did not significantly increase the risk for pneumonia (0.89 [0.78-1.01]). In conclusion, the treatment with proton pump inhibitors and H-2 receptor antagonists was associated with increased risk for pneumonia in stroke patients. Clinicians should use caution in prescribing the acid-suppressive medications for the stroke patients at great risk for pneumonia. | * |
dc.language | English | * |
dc.publisher | PUBLIC LIBRARY SCIENCE | * |
dc.title | Risk of post-stroke pneumonia with proton pump inhibitors, H-2 receptor antagonists and mucoprotective agents: A retrospective nationwide cohort study | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 14 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | PLOS ONE | * |
dc.identifier.doi | 10.1371/journal.pone.0216750 | * |
dc.identifier.wosid | WOS:000467373000060 | * |
dc.identifier.scopusid | 2-s2.0-85065638254 | * |
dc.author.google | Song, Tae-Jin | * |
dc.author.google | Kim, Jinkwon | * |
dc.contributor.scopusid | 송태진(55507164200) | * |
dc.date.modifydate | 20240304123954 | * |