Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.contributor.author | 서봉준 | * |
dc.date.accessioned | 2019-06-04T16:30:04Z | - |
dc.date.available | 2019-06-04T16:30:04Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 0360-3997 | * |
dc.identifier.issn | 1573-2576 | * |
dc.identifier.other | OAK-24864 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/249894 | - |
dc.description.abstract | The benzylideneacetophenone derivative JC3 [(2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one] (JC3) was synthesized by modifying yakuchinone B obtained from the seeds of Alpinia oxyphylla, a member of the ginger family (Zingiberaceae), which are widely used as a folk remedy and as an anti-inflammatory. The aim of this study was to investigate the anti-arthritic effects of JC3 in rat models of carrageenan-induced paw pain and carrageenan/kaolin-induced knee arthritis. The anti-nociceptive effect of JC3 was assessed by measuring paw withdrawal pressure thresholds using an analgesy-meter. Arthritic symptoms in our monoarthritic rat model were evaluated using weight distribution ratios (WDR), paw thicknesses, and serum prostaglandin E2 (PGE2), tumor necrosis factor (TNF)-, interleukin (IL)-6, and vascular endothelial growth factor (VEGF) levels (determined by ELISA). Histological analyses of knee joints were performed after injecting JC3 intraperitoneally into rats before carrageenan treatment at 5 or 10mg/kg/day for 6days. The anti-inflammatory effects of JC3 were investigated in vitro using interleukin-1beta (IL-1)-stimulated fibroblast-like synoviocytes (FLS) derived from arthritis patients. PGE2, IL-6, and IL-8 levels were measured after treating FLS with JC3. In arthritis-induced rats, JC3 treatment significantly decreased nociceptive and arthritic symptoms at days 5 to 6 after carrageenan/kaolin injection. Histological staining of knee tissue showed that JC3 significantly reduced inflammatory areas in the knee joints. Furthermore, JC3 inhibited the expressions of IL-6 and IL-8 in FLS cells at concentrations of 5-10g/ml and decreased PGE(2) levels in FLS cells. These findings suggest JC3 has anti-arthritic effects in in vivo and in vitro, and that it might be useful for the treatment of arthritis. | * |
dc.language | English | * |
dc.publisher | SPRINGER/PLENUM PUBLISHERS | * |
dc.subject | Arthritis | * |
dc.subject | Benzylideneacetophenone derivative | * |
dc.subject | Anti-inflammatory | * |
dc.subject | Fibroblast-like synoviocytes | * |
dc.title | Inhibition of Carrageenan/Kaolin-Induced Arthritis in Rats and of Inflammatory Cytokine Expressions in Human IL-1-Stimulated Fibroblast-like Synoviocytes by a Benzylideneacetophenone Derivative | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 42 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 928 | * |
dc.relation.lastpage | 936 | * |
dc.relation.journaltitle | INFLAMMATION | * |
dc.identifier.doi | 10.1007/s10753-018-0947-8 | * |
dc.identifier.wosid | WOS:000468517600017 | * |
dc.identifier.scopusid | 2-s2.0-85065978282 | * |
dc.author.google | Sur, Bongjun | * |
dc.author.google | Kang, Seungmin | * |
dc.author.google | Kim, Mijin | * |
dc.author.google | Oh, Seikwan | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.contributor.scopusid | 서봉준(26533542400) | * |
dc.date.modifydate | 20240429140616 | * |