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The breakdown of the local thermal equilibrium approximation for a polymer chain during packaging
- Title
- The breakdown of the local thermal equilibrium approximation for a polymer chain during packaging
- Authors
- Kwon, Seulki; Lee, Seulgi; Cho, Hyun Woo; Kim, Jeongmin; Kim, Jun Soo; Sung, Bong June
- Ewha Authors
- 김준수
- SCOPUS Author ID
- 김준수
- Issue Date
- 2019
- Journal Title
- JOURNAL OF CHEMICAL PHYSICS
- ISSN
- 0021-9606
1089-7690
- Citation
- JOURNAL OF CHEMICAL PHYSICS vol. 150, no. 20
- Publisher
- AMER INST PHYSICS
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The conformational relaxation of a polymer chain often slows down in various biological and engineering processes. The polymer, then, may stay in nonequilibrium states throughout the process such that one may not invoke the local thermal equilibrium (LTE) approximation, which has been usually employed to describe the kinetics of various processes. In this work, motivated by recent single-molecule experiments on DNA packaging into a viral capsid, we investigate how the nonequilibrium conformations and the LTE approximation would affect the packaging of a polymer chain into small confinement. We employ a simple but generic coarse-grained model and Langevin dynamics simulations to investigate the packaging kinetics. The polymer segments (both inside and outside the confinement) stay away from equilibrium under strong external force. We devise a simulation scheme to invoke the LTE approximation during packaging and find that the relaxation of nonequilibrium conformations plays a critical role in regulating the packaging rate. Published under license by AIP Publishing.
- DOI
- 10.1063/1.5093946
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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