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Interarm Blood Pressure Difference has Various Associations with the Presence and Burden of Cerebral Small-Vessel Diseases in Noncardioembolic Stroke Patients
- Interarm Blood Pressure Difference has Various Associations with the Presence and Burden of Cerebral Small-Vessel Diseases in Noncardioembolic Stroke Patients
- Chang, Yoonkyung; Lee, Seung Ah; Lee, Sue Hyun; Lee, Eun Hye; Kim, Yong-Jae; Song, Tae-Jin
- Ewha Authors
- 김용재; 송태진; 장윤경
- SCOPUS Author ID
- Issue Date
- Journal Title
- JOURNAL OF CLINICAL NEUROLOGY
- JOURNAL OF CLINICAL NEUROLOGY vol. 15, no. 2, pp. 159 - 167
- asymptomatic lacunar infarctions; cerebral microbleeds; cerebral small-vessel diseases; interarm blood pressure difference; white-matter hyperintensities
- KOREAN NEUROLOGICAL ASSOC
- SCIE; SCOPUS; KCI
- Document Type
- Background and Purpose An interarm blood pressure difference (IABD) is independently related to the occurrence of cardiovascular disease and mortality. Cerebral small-vessel diseases (SVDs) are important risk factors for stroke, cognitive dysfunction, and mortality. We aimed to determine whether IABD is related to cerebral SVDs. Methods This study included 1,205 consecutive noncardioembolic ischemic stroke patients as confirmed by brain MRI and simultaneously measured the bilateral brachial blood pressures. We investigated cerebral SVDs based on high-grade white-matter hyperintensities (HWHs), presence of cerebral microbleeds (CMBs), high-grade perivascular spaces (HPVSs), and asymptomatic lacunar infarctions (ALIs) on brain MRI. Results In multivariate logistic regression, an interarm systolic blood pressure difference (IASBD) >= 10 mm Hg was independently related to the existence of HWHs [odds ratio (OR)= 1.94, 95% CI=1.32-2.84, p=0.011] and had a tendency to be associated with the presence of HPVSs (OR=1.45, 95% CI=0.49-2.23, p=0.089) and ALIs (OR=1.42, 95% CI=0.96-2.11, p=0.052), but not with the presence of CMBs (OR=1.09, 95% CI=0.73-1.61, p=0.634). In multi-variate linear regression adjusted for age, sex, and variables with p<0.1 in the univariate analysis, IASBD >= 10 mm Hg and interarm diastolic blood pressure difference >= 10 mm Hg were significantly correlated with an increased total burden of SVDs (beta=0.080 and p=0.006, and beta=0.065 and p=0.023, respectively). Conclusions This study found that IABD >= 10 mm Hg was associated with the presence and increased burden of cerebral SVDs in noncardioembolic stroke patients. This suggests that IABD >= 10 mm Hg could be a useful indicator of the presence and burden of cerebral SVDs in stroke patients.
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