Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김규보 | * |
dc.date.accessioned | 2019-05-24T16:30:10Z | - |
dc.date.available | 2019-05-24T16:30:10Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1107-0625 | * |
dc.identifier.issn | 2241-6293 | * |
dc.identifier.other | OAK-24759 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/249866 | - |
dc.description.abstract | Purpose: The purpose of this study was to evaluate the differential effect of chemotherapy regimen in preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer. Methods: The medical records of 279 patients who underwent preoperative CRT followed by surgery for cT3/4 rectal cancer from 2003 to 2010 were retrospectively reviewed. Thirty-four patients were treated with one cycle of i.v. bolus 5-fluorouracil (5-FU) during 1st week (group A), 214 patients with two cycles of i.v. bolus 5-FU during 1st and 5th week (group B), and 31 patients with oral capecitabine on the days with radiotherapy (group C). Propensity score matching was performed between three groups. Results: Median follow-up was 60.1 months. Five-year locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), disease-free survival (DFS) and overall survival (OS) rates were 91.2, 83.3, 75.0, and 84.5%, respectively. Thirty-one patients per group were allocated to three groups via propensity score matching. On univariate analysis, concurrent chemotherapy regimen was not a significant prognostic factor for survival outcomes in the matched group analysis (OS, p=0.175; DFS, p=0.481; DMFS, p=0.515; LRFS, p=0.456). In addition, there was no significant difference in the sphincter preserving surgery rate, circumferential resection margin status, and pathologic response between three groups (p=0.441, 1.000, 0.818, respectively). As regards to treatment-related toxicity, 9 patients showed grade 3 neutropenia in group B, while there was no grade 3 or higher toxicity in groups A and C. Conclusion: The concurrent chemotherapy regimen (5-FU #1 vs 5-FU #2 vs capecitabine) did not have a significant effect on treatment outcomes in locally advanced rectal cancer patients receiving neoadjuvant CRT. | * |
dc.language | English | * |
dc.publisher | IMPRIMATUR PUBLICATIONS | * |
dc.subject | chemoradiotherapy | * |
dc.subject | chemotherapy regimen | * |
dc.subject | neoadjuvant | * |
dc.subject | rectal cancer | * |
dc.title | Differential effect of concurrent chemotherapy regimen on clinical outcomes of preoperative chemoradiotherapy for locally advanced rectal cancer | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 24 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 470 | * |
dc.relation.lastpage | 478 | * |
dc.relation.journaltitle | JOURNAL OF BUON | * |
dc.identifier.wosid | WOS:000464461100009 | * |
dc.author.google | Kim, Eunji | * |
dc.author.google | Kim, Kyubo | * |
dc.author.google | Oh, Do Hoon | * |
dc.author.google | Han, Sae-Won | * |
dc.author.google | Kim, Tae-You | * |
dc.author.google | Jung, Seung-Yong | * |
dc.author.google | Park, Kyu Joo | * |
dc.author.google | Kang, Gyeong Hoon | * |
dc.author.google | Chie, Eui Kyu | * |
dc.contributor.scopusid | 김규보(8213302900) | * |
dc.date.modifydate | 20240222162403 | * |