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Clinical outcomes of kidney transplantation in older end-stage renal disease patients: A nationwide cohort study
- Clinical outcomes of kidney transplantation in older end-stage renal disease patients: A nationwide cohort study
- Ko, Eun Jeong; Yang, Jaeseok; Ahn, Curie; Kim, Myoung Soo; Han, Duck Jong; Kim, Sung Joo; Yang, Chul Woo; Chung, Byung Ha; Chae, Dong Wan; Choi, Bum Soon; Jung, Cheol Woong; Kwon, Oh Jung; Kim, Sung-Joo; Kim, Yeong Hoon; Choi, SooJinNa; Han, Seung Yeup; Lee, Sang Ho; Jeong, Kyung Hwan; Kim, Seung Jung; Jeon, Jin Seok; Hyang, Soon Chun; Park, Yeon Ho; Roh, Young Nam; Lee, Jeong Joon; Lee, Kang Wook; Kim, Chan Duck; Park, Jong Won; Kim, Joong Kyung; Lee, Dong Ryeol; Lee, Dong Won; Seong, Eun Young; Kong, Jin Min; Cho, Hong Rae; Park, Sung Kwang; Lee, Sam Yeol; Park, Jung Hwan; Korean Organ Transplantation Regis
- Ewha Authors
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- Journal Title
- GERIATRICS & GERONTOLOGY INTERNATIONAL
- GERIATRICS & GERONTOLOGY INTERNATIONAL vol. 19, no. 5, pp. 392 - 398
- desensitization; elderly; kidney transplantation; patient mortality; sensitization
- SCIE; SSCI; SCOPUS
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- Aim The aim of the present study was to investigate the clinical outcomes of kidney transplantation (KT) in elderly recipients compared with those in young recipients. Methods We compared the incidence of biopsy-proven acute rejection, death-censored allograft survival and all-cause mortality, and also compared the impact of high sensitization or desensitization on the clinical outcomes of elderly and young recipients. Results A total of 4966 KT recipients from the Korean Organ Transplantation Registry were included. The definition of elderly recipients was based on age >60 years (n = 356), and recipients aged <60 years were defined as young recipients (n = 4610). The incidence of biopsy-proven acute rejection did not differ between the two groups irrespective of the donor type; however, the impact of high sensitization was significant only in young recipients. Being an elderly recipient was an independent risk factor for death-censored allograft failure in terms of overall and living donor KT, but not with deceased donor KT. In regard to patient death, being an elderly recipient was a significant predictor in general and in the two subgroups, and desensitization showed a significant interaction with death in the elderly recipients in the living donor KT group. Conclusions In conclusion, KT in elderly recipients might be associated with poor allograft or patient survival in general, and especially, desensitization therapy carried out in these patients might increase the risk of patient mortality. Geriatr Gerontol Int 2019; 19: 392-398.
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