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Clinical outcomes of kidney transplantation in older end-stage renal disease patients: A nationwide cohort study

Title
Clinical outcomes of kidney transplantation in older end-stage renal disease patients: A nationwide cohort study
Authors
Ko, Eun JeongYang, JaeseokAhn, CurieKim, Myoung SooHan, Duck JongKim, Sung JooYang, Chul WooChung, Byung HaChae, Dong WanChoi, Bum SoonJung, Cheol WoongKwon, Oh JungKim, Sung-JooKim, Yeong HoonChoi, SooJinNaHan, Seung YeupLee, Sang HoJeong, Kyung HwanKim, Seung JungJeon, Jin SeokHyang, Soon ChunPark, Yeon HoRoh, Young NamLee, Jeong JoonLee, Kang WookKim, Chan DuckPark, Jong WonKim, Joong KyungLee, Dong RyeolLee, Dong WonSeong, Eun YoungKong, Jin MinCho, Hong RaePark, Sung KwangLee, Sam YeolPark, Jung HwanKorean Organ Transplantation Regis
Ewha Authors
김승정
SCOPUS Author ID
김승정scopus
Issue Date
2019
Journal Title
GERIATRICS & GERONTOLOGY INTERNATIONAL
ISSN
1444-1586JCR Link

1447-0594JCR Link
Citation
GERIATRICS & GERONTOLOGY INTERNATIONAL vol. 19, no. 5, pp. 392 - 398
Keywords
desensitizationelderlykidney transplantationpatient mortalitysensitization
Publisher
WILEY
Indexed
SCIE; SSCI; SCOPUS WOS scopus
Document Type
Article
Abstract
Aim The aim of the present study was to investigate the clinical outcomes of kidney transplantation (KT) in elderly recipients compared with those in young recipients. Methods We compared the incidence of biopsy-proven acute rejection, death-censored allograft survival and all-cause mortality, and also compared the impact of high sensitization or desensitization on the clinical outcomes of elderly and young recipients. Results A total of 4966 KT recipients from the Korean Organ Transplantation Registry were included. The definition of elderly recipients was based on age >60 years (n = 356), and recipients aged <60 years were defined as young recipients (n = 4610). The incidence of biopsy-proven acute rejection did not differ between the two groups irrespective of the donor type; however, the impact of high sensitization was significant only in young recipients. Being an elderly recipient was an independent risk factor for death-censored allograft failure in terms of overall and living donor KT, but not with deceased donor KT. In regard to patient death, being an elderly recipient was a significant predictor in general and in the two subgroups, and desensitization showed a significant interaction with death in the elderly recipients in the living donor KT group. Conclusions In conclusion, KT in elderly recipients might be associated with poor allograft or patient survival in general, and especially, desensitization therapy carried out in these patients might increase the risk of patient mortality. Geriatr Gerontol Int 2019; 19: 392-398.
DOI
10.1111/ggi.13630
Appears in Collections:
의과대학 > 의학과 > Journal papers
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