View : 151 Download: 0

Clinical outcomes of patients with active rheumatoid arthritis with normal acute phase reactant values

Title
Clinical outcomes of patients with active rheumatoid arthritis with normal acute phase reactant values
Authors
Chung, Min KyungPark, BohyunKim, In JeCho, Soo-KyungKim, DamSung, Yoon-KyoungChoi, Chan-BumChoe, Jung-YoonChung, Won TaeHong, Seung-JaeKim, Tae-HwanKoh, EunmiLee, Shin-SeokYoon, Bo YoungPark, HyesookBae, Sang-CheolLee, Jisoo
Ewha Authors
박혜숙이지수박보현김인제정민경
SCOPUS Author ID
박혜숙scopus; 이지수scopus; 박보현scopus; 김인제scopus
Issue Date
2019
Journal Title
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
ISSN
1756-1841JCR Link

1756-185XJCR Link
Citation
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES vol. 22, no. 5, pp. 852 - 859
Keywords
activeacute-phase proteinnormalrheumatoid arthritis
Publisher
WILEY
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Aim Despite high clinical disease activity, some patients with active rheumatoid arthritis (RA) have normal acute phase reactant (APR) values. This study aimed to determine the clinical outcomes of active RA patients with normal APR values. Method Of 5376 patients with RA enrolled in the Korean observational study network for arthritis (KORONA) registry, 400 patients with disease duration of <2 years who had Clinical Disease Activity Index (CDAI) score of >2.8 at baseline, biologic-naive, and erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) drawn at both baseline and 2-year follow-up visits were identified. Patients were grouped according to baseline APR levels: normal APRs, one APR elevated, and both APRs elevated. Results Baseline tender and swollen joint counts, mean CDAI and Health Assessment Questionnaire-Disability Index (HAQ-DI) scores were significantly lower in the normal APRs group compared with APR-elevated groups (P < 0.0001). At 2-year follow-up, mean CDAI scores, HAQ-DI, and percentage of the patient achieving remission were not significantly different between the normal APRs group compared with the APR-elevated groups regardless of the baseline disease activity. However, in patients with baseline CDAI moderate to high disease activity, the normal APRs group less frequently required initiation of the biologic disease-modifying anti-rheumatic drugs compared with the APR-elevated groups (P = 0.044). Conclusion Active RA patients with normal APR values have milder disease presentation, but similar clinical outcomes to those with elevated APRs.
DOI
10.1111/1756-185X.13469
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE