View : 151 Download: 0
Clinical outcomes of patients with active rheumatoid arthritis with normal acute phase reactant values
- Clinical outcomes of patients with active rheumatoid arthritis with normal acute phase reactant values
- Chung, Min Kyung; Park, Bohyun; Kim, In Je; Cho, Soo-Kyung; Kim, Dam; Sung, Yoon-Kyoung; Choi, Chan-Bum; Choe, Jung-Yoon; Chung, Won Tae; Hong, Seung-Jae; Kim, Tae-Hwan; Koh, Eunmi; Lee, Shin-Seok; Yoon, Bo Young; Park, Hyesook; Bae, Sang-Cheol; Lee, Jisoo
- Ewha Authors
- 박혜숙; 이지수; 박보현; 김인제; 정민경
- SCOPUS Author ID
- 박혜숙; 이지수; 박보현; 김인제
- Issue Date
- Journal Title
- INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
- INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES vol. 22, no. 5, pp. 852 - 859
- active; acute-phase protein; normal; rheumatoid arthritis
- SCIE; SCOPUS
- Document Type
- Aim Despite high clinical disease activity, some patients with active rheumatoid arthritis (RA) have normal acute phase reactant (APR) values. This study aimed to determine the clinical outcomes of active RA patients with normal APR values. Method Of 5376 patients with RA enrolled in the Korean observational study network for arthritis (KORONA) registry, 400 patients with disease duration of <2 years who had Clinical Disease Activity Index (CDAI) score of >2.8 at baseline, biologic-naive, and erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) drawn at both baseline and 2-year follow-up visits were identified. Patients were grouped according to baseline APR levels: normal APRs, one APR elevated, and both APRs elevated. Results Baseline tender and swollen joint counts, mean CDAI and Health Assessment Questionnaire-Disability Index (HAQ-DI) scores were significantly lower in the normal APRs group compared with APR-elevated groups (P < 0.0001). At 2-year follow-up, mean CDAI scores, HAQ-DI, and percentage of the patient achieving remission were not significantly different between the normal APRs group compared with the APR-elevated groups regardless of the baseline disease activity. However, in patients with baseline CDAI moderate to high disease activity, the normal APRs group less frequently required initiation of the biologic disease-modifying anti-rheumatic drugs compared with the APR-elevated groups (P = 0.044). Conclusion Active RA patients with normal APR values have milder disease presentation, but similar clinical outcomes to those with elevated APRs.
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.