View : 211 Download: 0

Reciprocal interactions across and within multiple levels of monoamine and cortico-limbic systems in stress-induced depression: A systematic review

Title
Reciprocal interactions across and within multiple levels of monoamine and cortico-limbic systems in stress-induced depression: A systematic review
Authors
Lee, Eun-HwaHan, Pyung-Lim
Ewha Authors
한평림
SCOPUS Author ID
한평림scopus
Issue Date
2019
Journal Title
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
ISSN
0149-7634JCR Link

1873-7528JCR Link
Citation
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS vol. 101, pp. 13 - 31
Keywords
MonoaminesCortico-limbic systemDepressionStressNeural circuit activityAnimal models
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
The monoamine hypothesis of depression, namely that the reduction in synaptic serotonin and dopamine levels causes depression, has prevailed in past decades. However, clinical and preclinical studies have identified various cortical and subcortical regions whose altered neural activities also regulate depressive-like behaviors, independently from the monoamine system. Our systematic review indicates that neural activities of specific brain regions and associated neural circuitries are adaptively altered after chronic stress in a specific direction, such that the neural activity in the infralimbic cortex, lateral habenula and amygdala is upregulated, whereas the neural activity in the prelimbic cortex, hippocampus and monoamine systems is downregulated. The altered neural activity dynamics between monoamine systems and cortico-limbic systems are reciprocally interwoven at multiple levels. Furthermore, depressive-like behaviors can be experimentally reversed by counteracting the altered neural activity of a specific neural circuitry at multiple brain regions, suggesting the importance of the reciprocally interwoven neural networks in regulating depressive-like behaviors. These results promise for reshaping altered neural activity dynamics as a therapeutic strategy for treating depression.
DOI
10.1016/j.neubiorev.2019.03.014
Appears in Collections:
일반대학원 > 뇌·인지과학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE