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Epigenetic memory in gene regulation and immune response

Title
Epigenetic memory in gene regulation and immune response
Authors
Kim, Min YoungLee, Ji EunKim, Lark KyunKim, TaeSoo
Ewha Authors
김태수이지은
SCOPUS Author ID
김태수scopus
Issue Date
2019
Journal Title
BMB REPORTS
ISSN
1976-6696JCR Link

1976-670XJCR Link
Citation
BMB REPORTS vol. 52, no. 2, pp. 127 - 132
Keywords
H3K4me3Rpd3L HDACTrained ImmunityTranscriptional memoryTranscriptional Repression Memory (TREM)
Publisher
KOREAN SOCIETY BIOCHEMISTRY &

MOLECULAR BIOLOGY
Indexed
SCIE; SCOPUS; KCI WOS
Document Type
Review
Abstract
Cells must fine-tune their gene expression programs for optimal cellular activities in their natural growth conditions. Transcriptional memory, a unique transcriptional response, plays a pivotal role in faster reactivation of genes upon environmental changes, and is facilitated if genes were previously in an active state. Hyper-activation of gene expression by transcriptional memory is critical for cellular differentiation, development, and adaptation. TREM (Transcriptional REpression Memory), a distinct type of transcriptional memory, promoting hyper-repression of unnecessary genes, upon environmental changes has been recently reported. These two transcriptional responses may optimize specific gene expression patterns, in rapidly changing environments. Emerging evidence suggests that they are also critical for immune responses. In addition to memory B and T cells, innate immune cells are transcriptionally hyperactivated by restimulation, with the same or different pathogens known as trained immunity. In this review, we briefly summarize recent progress in chromatin-based regulation of transcriptional memory, and its potential role in immune responses.
DOI
10.5483/BMBRep.2019.52.2.257
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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