Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희선 | * |
dc.contributor.author | 박진선 | * |
dc.contributor.author | 임예현 | * |
dc.date.accessioned | 2019-04-23T16:30:02Z | - |
dc.date.available | 2019-04-23T16:30:02Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1976-9148 | * |
dc.identifier.other | OAK-24557 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/249677 | - |
dc.description.abstract | Parkinson’s disease is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta. In the present study, we investigated whether β-Lapachone (β-LAP), a natural naphthoquinone compound isolated from the lapacho tree (Tabebuia avellanedae), elicits neuroprotective effects in a 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced Parkinson’s disease mouse model. β-LAP reduced the tyrosine hydroxylase (TH)-immunoreactive fiber loss induced by MPTP in the dorsolateral striatum, and alleviated motor dysfunction as determined by the rotarod test. In addition, β-LAP protected against MPTP-induced loss of TH positive neurons, and upregulated B-cell lymphoma 2 protein (Bcl-2) expression in the substantia nigra. Based on previous reports on the neuroprotective role of nuclear factor-E2-related factor- 2 (Nrf2) in neurodegenerative diseases, we investigated whether β-LAP induces upregulation of the Nrf2-hemeoxygenae-1 (HO-1) signaling pathway molecules in MPTP-injected mouse brains. Western blot and immunohistochemical analyses indicated that β-LAP increased HO-1 expression in glial fibrillary acidic protein-positive astrocytes. Moreover, β-LAP increased the nuclear translocation and DNA binding activity of Nrf2, and the phosphorylation of upstream adenosine monophosphate-activated protein kinase (AMPK). β-LAP also increased the localization of p-AMPK and Nrf2 in astrocytes. Collectively, our data suggest that β-LAP exerts neuroprotective effect in MPTP-injected mice by upregulating the p-AMPK/Nrf2/HO-1 signaling pathways in astrocytes. © 2019 The Korean Society of Applied Pharmacology. | * |
dc.language | English | * |
dc.publisher | Korean Society of Applied Pharmacology | * |
dc.subject | Astrocyte | * |
dc.subject | Neuroprotection | * |
dc.subject | Nrf2/HO-1 signaling | * |
dc.subject | Parkinson’s disease | * |
dc.subject | β-Lapachone | * |
dc.title | Neuroprotective effect of β-lapachone in MPTP-induced parkinson’s disease mouse model: Involvement of astroglial p-AMPK/Nrf2/HO-1 signaling pathways | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 27 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 178 | * |
dc.relation.lastpage | 184 | * |
dc.relation.journaltitle | Biomolecules and Therapeutics | * |
dc.identifier.doi | 10.4062/biomolther.2018.234 | * |
dc.identifier.wosid | WOS:000460170100007 | * |
dc.identifier.scopusid | 2-s2.0-85067075234 | * |
dc.author.google | Park J.-S. | * |
dc.author.google | Leem Y.-H. | * |
dc.author.google | Park J.-E. | * |
dc.author.google | Kim D.-Y. | * |
dc.author.google | Kim H.-S. | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.contributor.scopusid | 박진선(54914743600) | * |
dc.contributor.scopusid | 임예현(25422269100) | * |
dc.date.modifydate | 20240222143226 | * |