Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김형래 | * |
dc.date.accessioned | 2019-04-23T16:30:02Z | - |
dc.date.available | 2019-04-23T16:30:02Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 2077-0383 | * |
dc.identifier.other | OAK-24558 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/249676 | - |
dc.description.abstract | The changes in the gut microbiota of healthy hepatitis B virus (HBV) carriers, including asymptomatic and non-cirrhotic subjects, have been rarely scrutinized. From 1463 faecal samples in health examinees, in total 112 subjects, including 36 hepatitis B surface antigen (HBsAg)-positive and 76 control subjects, were included. Twenty-eight of 36 HBsAg-positive individuals (78%) showed normal alanine aminotransferase (ALT) levels (normal ALT group), whereas eight subjects exhibited elevated ALT levels (22%, high ALT group). By using 16S rRNA gene sequencing, the distance between normal and high ALT groups among HBsAg-positive subjects showed a significant separation after the pairwise comparison of weighted UniFrac distance (permutational analysis of variance q-value = 0.039), when compared with the distances to the control group. In comparison with the control group, the normal ALT group had Anaerostipes as a significant taxon that showed a positive association (Coefficient (Coef.) = 0.028, q = 0.039). Desulfovibrio (Coef. = 0.54, q = 0.014) and Megasphaera (Coef. = 1.41, q = 0.030) showed positive correlations, and Acidaminococcus (Coef. = -1.31, q = 4.15 x 10(-75)) exhibited a negative correlation with high ALT level. Gut microbial composition was different according to HBV-induced serum ALT levels, indicative of a potential link between gut and liver metabolism. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | hepatitis B virus | * |
dc.subject | gut microbiome | * |
dc.subject | Megasphaera | * |
dc.title | Alterations of the Gut Microbiome in Chronic Hepatitis B Virus Infection Associated with Alanine Aminotransferase Level | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 8 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | JOURNAL OF CLINICAL MEDICINE | * |
dc.identifier.doi | 10.3390/jcm8020173 | * |
dc.identifier.wosid | WOS:000460295400046 | * |
dc.author.google | Yun, Yeojun | * |
dc.author.google | Chang, Yoosoo | * |
dc.author.google | Kim, Han-Na | * |
dc.author.google | Ryu, Seungho | * |
dc.author.google | Kwon, Min-Jung | * |
dc.author.google | Cho, Yong Kyun | * |
dc.author.google | Kim, Hyung-Lae | * |
dc.author.google | Cheong, Hae Suk | * |
dc.author.google | Joo, Eun-Jeong | * |
dc.contributor.scopusid | 김형래(57202558385;57219111690;57567109600) | * |
dc.date.modifydate | 20240118123830 | * |