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Predicting behavior problems in korean preschoolers: interactions of the SLC6A4 gene and maternal negative affectivity

Title
Predicting behavior problems in korean preschoolers: interactions of the SLC6A4 gene and maternal negative affectivity
Authors
Ha J.Jun H.J.Shin H.Chung I.J.Park E.Min S.K.Kim E.
Ewha Authors
정익중
SCOPUS Author ID
정익중scopus
Issue Date
2019
Journal Title
Clinical Psychopharmacology and Neuroscience
ISSN
1738-1088JCR Link
Citation
Clinical Psychopharmacology and Neuroscience vol. 17, no. 2, pp. 200 - 210
Keywords
Child behaviorGene-environment interactionMaternal behaviorSLC6A4 protein
Publisher
Korean College of Neuropsychopharmacology
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
Objective: This study aimed to investigate whether maternal negative affectivity (MNA) moderates the effect of genetic polymorphism of SLC6A4 on behavior problems in children. Methods: Study participants comprised 143 preschoolers and their mothers from South Korea. The Childhood Behavior Checklist and Emotionality, Activity, and Sociability adult scale were used to measure child behavior and maternal affectivity. DNA from saliva was genotyped to determine serotonin transporter polymorphism. Results: MNA appeared to exert effects in externalizing (b =5.78, p0.001) and internalizing problems (b =6.09, p0.001). Interaction between SLCA4 polymorphism and MNA showed effects on externalizing (b =7.62, p0.01) and internalizing problems (b =9.77, p0.01). Children with two short alleles showed considerable differences in both externalizing and internalizing problems according to MNA; however, children with one short allele or none showed relatively few differences in behavior problems due to maternal affectivity. Conclusion: The effect of SLC6A4 polymorphism on child behavior seemed to be moderated by MNA. In addition, the impact of MNA was found to vary based on a child's genetic risk. High MNA may trigger the risk allele while low MNA causes the risk allele to illicit less behavior problems. Children with two short variants of the SLC6A4 gene may benefit from intervention that modulates MNA. © 2019 Korean College of Neuropsychopharmacology. All rights reserved.
DOI
10.9758/cpn.2019.17.2.200
Appears in Collections:
사회과학대학 > 사회복지학전공 > Journal papers
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