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Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae: A Potential Platform Microorganism for Biorefineries

Title
Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae: A Potential Platform Microorganism for Biorefineries
Authors
Rhie, Mi NaKim, Hee TaekJo, Seo YoungChu, Luan LuongBaritugo, Kei-AnneBaylon, Mary GraceLee, JinwonNa, Jeong-GeolKim, Lyul HoKim, Tae WanPark, ChulhwanHong, Soon HoJoo, Jeong ChanPark, Si Jae
Ewha Authors
박시재
SCOPUS Author ID
박시재scopus
Issue Date
2019
Journal Title
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
ISSN
1226-8372JCR Link

1976-3816JCR Link
Citation
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING vol. 24, no. 1, pp. 48 - 64
Keywords
Klebsiella pneumoniaebiorefinerymetabolic engineeringmicrobial cell factorycarbon utilizationbiomass
Publisher
KOREAN SOC BIOTECHNOLOGY &

BIOENGINEERING
Indexed
SCIE; SCOPUS; KCI WOS
Document Type
Review
Abstract
The production of industrial chemicals from renewable biomass resources is a promising solution to overcome the society's dependence on petroleum and to mitigate the pollution resulting from petroleum processing. Klebsiella pneumoniae is a nutritionally versatile bacterium with numerous native pathways for the production of well-known and industrially important platform chemicals derived from various sugars. Genomic sequence analyses have shown that the K. pneumoniae genome has a high similarity with that of Escherichia coli, the most studied organism, which is used in industrial biotechnology processes for fuel and chemical production. Hence, K. pneumoniae can be considered as a promising platform microorganism that can be metabolically engineered for the high-level production of bio-based chemicals. This review highlights the substrate metabolism and the metabolic engineering strategies developed in K. pneumoniae for the production of bio-based chemicals.
DOI
10.1007/s12257-018-0346-x
Appears in Collections:
엘텍공과대학 > 화학신소재공학전공 > Journal papers
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