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Exposure to prenatal secondhand smoke and early neurodevelopment: Mothers and Children's Environmental Health (MOCEH) study

Title
Exposure to prenatal secondhand smoke and early neurodevelopment: Mothers and Children's Environmental Health (MOCEH) study
Authors
Lee, MyeongjeeHa, MinaHong, Yun-ChulPark, HyesookKim, YanghoKim, Eui-JungKim, YeniHa, Eunhee
Ewha Authors
하은희박혜숙이명지
SCOPUS Author ID
하은희scopus; 박혜숙scopus
Issue Date
2019
Journal Title
ENVIRONMENTAL HEALTH
ISSN
1476-069XJCR Link
Citation
ENVIRONMENTAL HEALTH vol. 18
Keywords
Secondhand smokeUrine cotinineInfant neurodevelopmentGenetic polymorphismBreastfeeding24months
Publisher
BMC
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
BackgroundThe association between exposure to secondhand smoke (SHS) during pregnancy and a child's neurodevelopment has not been established yet. We explored the association between prenatal exposure to SHS and neurodevelopment at 24months of age considering genetic polymorphism and breastfeeding in 720 mothers and their offspring enrolled in the Korean multicenter birth cohort study (Mothers and Children Environmental Health, MOCEH).MethodsWe quantified urine cotinine concentrations in mothers once from 12th to 20th gestational weeks and excluded those whose urine cotinine levels exceeded 42.7ng/ml to represent SHS exposure in early pregnancy. Mental developmental index (MDI) and psychomotor developmental index (PDI) values were measured using the Korean version of the Bayley Scales of Infant Development II (K-BSID-II) at 24months of age. A general linear model was used to assess the relationship between maternal urinary cotinine level and neurodevelopment.ResultsMDI scores were inversely associated with cotinine [=-2.73; 95% confidence interval (CI): -5.32 to -0.15] in children whose mothers had early pregnancy urinary cotinine levels >1.90ng/ml. No association was evident in children whose mothers had cotinine levels 1.90ng/ml. This negative association was more pronounced in children whose mothers had both Glutathione S-transferases mu 1 (GSTM1) and theta 1 (GSTT1) null type [=-5.78; 95% CI: -10.69 to -0.87], but not in children whose mothers had any present type of GSTM1/GSTT1 [=-1.64; 95% CI: -4.79 to 1.52]. The association was no longer significant when children received breast milk exclusively for up to 6months [=-0.24; 95% CI: -4.69 to 4.20] compared to others [=-3.75; 95% CI: -7.51 to 0.00]. No significant association was found for PDI.ConclusionsMaternal exposure to SHS during pregnancy may result in delayed MDI in early childhood. This effect might be modified by genetic polymorphism and breastfeeding behavior.
DOI
10.1186/s12940-019-0463-9
Appears in Collections:
의과대학 > 의학과 > Journal papers
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