View : 50 Download: 0
Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide
- Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide
- Piano, Salvatore; Singh, Virendra; Caraceni, Paolo; Maiwall, Rakhi; Alessandria, Carlo; Fernandez, Javier; Soares, Elza Cotrim; Kim, Dong Joon; Kim, Sung Eun; Marino, Monica; Vorobioff, Julio; Ribeiro Barea, Rita de Cassia; Merli, Manuela; Elkrief, Laure; Vargas, Victor; Krag, Aleksander; Singh, Shivaram Prasad; Lesmana, Laurentius Adrianto; Toledo, Claudio; Marciano, Sebastian; Verhelst, Xavier; Wong, Florence; Intagliata, Nicolas; Rabinowich, Liane; Colombato, Luis; Kim, Sang Gyune; Gerbes, Alexander; Durand, Francois; Pablo Roblero, Juan; Bhamidimarri, Kalyan Ram; Boyer, Thomas D.; Maevskaya, Marina; Fassio, Eduardo; Kim, Hyoung Su; Hwang, Jae Seok; Gines, Pere; Gadano, Adrian; Sarin, Shiv Kumar; Angeli, Paolo; Bartoletti, Michele; Brodersen, Carlos; Bruns, Tony; de Man, Robert A.; Fialla, Annette Dam; Gambino, Carmine; Gautam, Vikas; Girala, Marcos; Juanola, Adria; Kim, Jeong Han; Kim, Tae Hun; Kumar, Pramod; Lattanzi, Barbara; Lee, Tae Hee; Lesmana, Cosmas A. Rinaldi; Moreau, Richard; Nath, Preetam; Navarro, Gustavo; Park, Ji-Won; Pinero, Gisela; Pyrsopoulos, Nikolaos T.; Restellini, Sophie; Romero, Gustavo; Sacco, Marco; Seva-Pereira, Tiago; Simon-Talero, Macarena; Song, Do Seon; Suk, Ki Tae; Van Vlierberghe, Hans; Yim, Sun Young; Yoon, Eileen Laurel; Zaccherini, Giacomo; Int Club Ascites Global Study Grp
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- GASTROENTEROLOGY vol. 156, no. 5, pp. 1368 - +
- Global; Resistance; Sepsis; Stewardship
- W B SAUNDERS CO-ELSEVIER INC
- SCI; SCIE; SCOPUS
- Document Type
- BACKGROUND & AIMS: Bacterial infections are common and life-threatening in patients with cirrhosis. Little is known about the epidemiology of bacterial infections in different regions. We performed a multicenter prospective intercontinental study to assess the prevalence and outcomes of bacterial and fungal infections in patients with cirrhosis. METHODS: We collected data from 1302 hospitalized patients with cirrhosis and bacterial or fungal infections at 46 centers (15 in Asia, 15 in Europe, 11 in South America, and 5 in North America) from October 2015 through September 2016. We obtained demographic, clinical, microbiology, and treatment data at time of diagnosis of infection and during hospitalization. Patients were followed until death, liver transplantation, or discharge. RESULTS: The global prevalence of multidrug-resistant (MDR) bacteria was 34% (95% confidence interval 31%-37%). The prevalence of MDR bacteria differed significantly among geographic areas, with the greatest prevalence in Asia. Independent risk factors for infection with MDR bacteria were infection in Asia (particularly in India), use of antibiotics in the 3 months before hospitalization, prior health care exposure, and site of infection. Infections caused by MDR bacteria were associated with a lower rate of resolution of infection, a higher incidence of shock and new organ failures, and higher in-hospital mortality than those caused by non-MDR bacteria. Administration of adequate empirical antibiotic treatment was independently associated with improved in-hospital and 28-day survival. CONCLUSIONS: In a worldwide study of hospitalized patients, we found a high prevalence of infection with MDR bacteria in patients with cirrhosis. Differences in the prevalence of MDR bacterial infections in different global regions indicate the need for different empirical antibiotic strategies in different continents and countries. While we await new antibiotics, effort should be made to decrease the spread of MDR bacteria in patients with cirrhosis.
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.