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Morphine Dependence is Attenuated by Treatment of 3,4,5-Trimethoxy Cinnamic Acid in Mice and Rats
- Title
- Morphine Dependence is Attenuated by Treatment of 3,4,5-Trimethoxy Cinnamic Acid in Mice and Rats
- Authors
- Moon, Sohyeon; Kang, Seungmin; Shin, Heeyeon; Yayeh, Taddesse; Sur, Bongjun; Oh, Seikwan
- Ewha Authors
- 오세관; 서봉준
- SCOPUS Author ID
- 오세관; 서봉준
- Issue Date
- 2019
- Journal Title
- NEUROCHEMICAL RESEARCH
- ISSN
- 0364-3190
1573-6903
- Citation
- NEUROCHEMICAL RESEARCH vol. 44, no. 4, pp. 874 - 883
- Keywords
- 3; 4; 5-Trimethoxy cinnamic acid (TMCA); Morphine dependence; NMDA; Nucleus accumbens; FosB
- Publisher
- SPRINGER/PLENUM PUBLISHERS
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The effect of 3, 4, 5-trimethoxy cinnamic acid (TMCA) against morphine-induced dependence in mice and rats was investigated. Mice were pretreated with TMCA and then morphine was injected intraperitoneally; whereas rats were treated with TMCA (i.p.) and infused with morphine into the lateral ventricle of brain. Naloxone-induced morphine withdrawal syndrome and conditioned place preference test were performed. Moreover, western blotting and immunohistochemistry were used to measure protein expressions. Number of naloxone-precipitated jumps and conditioned place preference score in mice were attenuated by TMCA. Likewise, TMCA attenuated morphine dependent behavioral patterns such as diarrhea, grooming, penis licking, rearing, teeth chattering, and vocalization in rats. Moreover, the expression levels of pNR1and pERK in the frontal cortex of mice and cultured cortical neurons were diminished by TMCA. In the striatum, pERK expression was attenuated despite unaltered expression of pNR1 and NR1. Interestingly, morphine-induced elevations of FosB/FosB(+) cells were suppressed by TMCA (50, 100mg/kg) in the nucleus accumbens sub-shell region of mice. In conclusion, TMCA could be considered as potential therapeutic agent against morphine-induced dependence.
- DOI
- 10.1007/s11064-019-02720-9
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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